Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0140-6736(96)91473-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
HHV-8-associated diseases in transplantation: A case report and narrative review focused on diagnosis and prevention.
Transpl Infect Dis
November 2024
HIV & AIDS Malignancy Branch, Center for Cancer Research, NCI, Bethesda, Maryland, USA.
Article Synopsis
- HHV-8 (Kaposi sarcoma herpesvirus) is linked to serious illnesses including Kaposi sarcoma and lymphoproliferative disorders, particularly affecting transplant recipients.
- A case study highlighted a fatal outcome linked to HHV-8, prompting a review of its impact on immunocompromised patients and exploring disease transmission and the importance of screening donors and recipients.
- The study concludes that while HHV-8 diseases can be severe and multifaceted in transplant patients, the actual risk of donor-derived infections is not well understood and needs more research.
Biologically significant interaction of human herpesvirus 8 viral interferon regulatory factor 4 with ubiquitin-specific protease 7.
J Virol
June 2024
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Unlabelled: Human herpesvirus 8 (HHV-8), associated with Kaposi sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman disease, encodes four interferon regulatory factor homologs, vIRFs 1-4, that interact with and inhibit various mediators of host-cell defense against virus infection. A cellular protein targeted by all the vIRFs is ubiquitin-specific protease 7 (USP7); while replication-modulatory and latently infected PEL-cell pro-viability phenotypes of USP7 targeting have been identified for vIRFs 1-3, the significance of the interaction of vIRF-4 with USP7 has remained undetermined. Here we show, through genetic ablation of the vIRF-4-USP7 interaction in infected cells, that vIRF-4 association with USP7 is necessary for optimal expression of vIRF-4 and normal HHV-8 replication.
View Article and Find Full Text PDFA variant of KSHV-associated inflammatory cytokine syndrome in elderly men of Mediterranean descent.
Infection
June 2024
Department of Hematology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
The spectrum of HHV-8-associated disorders includes Kaposi's sarcoma, primary effusion lymphoma, multicentric Castleman's disease, and the recently described KSHV inflammatory cytokine syndrome (KICS), a life-threatening disorder complicating HIV infection. There have been no reports in the literature concerning non-immunosuppressed individuals affected with KICS. We report here a KICS-like illness occurring in two elderly Greek men without HIV infection or other recognizable cause of immunosuppression.
View Article and Find Full Text PDFDemographic profile, management, and survival of primary Gastrointestinal Kaposi Sarcoma: A USA Nationwide SEER-based study.
Cancer Epidemiol
December 2022
Division of Gastroenterology, Hepatology and Nutrition, University of Texas, 6431, Fannin, Houston, TX 77030, USA; Mercer University School of Medicine Macon, GA 31207, USA. Electronic address:
Kaposi Sarcoma (KS) is a Human Herpes Virus-8 (HHV-8) associated angio-proliferative disorder commonly seen in patients with HIV. It most commonly involves the skin as classic purple lesions but occasionally involves the gastrointestinal (GI) tract. To date, published data is scarce on primary GI KS.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!