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Stability of antipsychotic biomarkers for wastewater-based epidemiology.
J Pharm Biomed Anal
January 2025
Jožef Stefan Institute, Jamova 39, Ljubljana 1000, Slovenia; Jožef Stefan International Postgraduate School, Jamova 39, Ljubljana 1000, Slovenia. Electronic address:
Wastewater-based epidemiology (WBE) offers a promising approach by providing objective data on antipsychotic drug consumption within a population that can be used to monitor abuse, misuse, and regional prescription patterns. However, accurate estimations depend on knowing the stability of drug biomarkers. This study provides a comprehensive analysis of the stability of 11 antipsychotic biomarkers (parent drugs and their metabolites) in influent wastewater, using a series of experiments mimicking in-sewer transport (in-sewer setup and deconjugation) and in-sample stability (benchtop, frozen cartridge, long-term sample storage, and freeze-thaw).
View Article and Find Full Text PDFFatal overdoses among people with HIV experiencing nonfatal overdoses in British Columbia, Canada.
AIDS
March 2025
Faculty of Health Sciences, Simon Fraser University, Burnaby.
The breadth of the overdose crisis is underestimated because of a lack of quantifying nonfatal overdoses. We estimate the proportion of nonfatal overdoses among all people with HIV (PWH) in British Columbia, Canada, and the prevalence of fatal overdoses among people who had a nonfatal overdose, stratified by sex. A small proportion of PWH who experienced a nonfatal overdose subsequently died of a fatal overdose, signaling opportunities for crucial interventions and treatment to prevent overdose death.
View Article and Find Full Text PDFAssessing Prevalence of Nonmedically Used Prescription Drug Involvement in Overdose Deaths Through Linkage of State Unintentional Drug Overdose Reporting System and Controlled Substances Monitoring Program Data.
Subst Use Misuse
January 2025
Tennessee Department of Health, Office of Informatics and Analytics, Nashville, TN, USA.
Background: While illicit substances are commonly involved in the overdose crisis, prescription substances still play a role. Oftentimes, decedents do not have prescriptions for these substances at the time of death. As such, we sought to examine the prevalence of nonmedical drug use in Tennessee through linkage of fatal drug overdose and prescription data.
View Article and Find Full Text PDFEmpowerment in prevention: a qualitative inquiry into Black girl-centred strategies for reducing HIV/STI and drug misuse risk.
Sex Reprod Health Matters
January 2025
Research Scientist, Yale School of Public Health, New Haven CT, USA.
Black girls in the United States are disproportionately diagnosed with sexually transmitted infections (STIs), which can increase the risk of contracting HIV (human immunodeficiency virus), compared to adolescent girls of other races. Therefore, this study was designed to understand barriers to impactful HIV/STI and substance use prevention programmes for Black girls. Data was collected between October 2021 and June 2022 from twelve focus groups which included (N = 62) participants who identified as Black and female between the ages of 13 and 18 years old.
View Article and Find Full Text PDFAssessing fentanyl and methamphetamine in air and on surfaces of transit vehicles.
J Occup Environ Hyg
January 2025
Department of Environmental and Occupational Health Sciences, University of Washington School of Public Health, Seattle, Washington.
Recently, the misuse of fentanyl and methamphetamine has increased in the United States. These drugs can be consumed via smoking a powder, which can subsequently contaminate air and surfaces with drug residue. With limited access to safe consumption sites, this misuse often occurs in public spaces such as public transit, leading to potential secondhand exposures among transit operators and riders.
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