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Olive leaf extract (OLE) reduces mast cell-mediated allergic inflammation.
Biomed Pharmacother
January 2025
Department of Pharmacy, School of Medicine, University of Naples Federico II, Naples, Italy. Electronic address:
Mast cell-mediated reactions promote various allergic disease, including anaphylaxis, allergic rhinitis, asthma, and atopic dermatitis. Different data demonstrated an intricate relationship between the use of antihistaminic drugs, the onset of side effects, and the development of resistance, underscoring the importance to find novel therapeutic approaches to treat allergic diseases. Olive leaf extract (OLE), is a by-product of the olive tree rich in bioactive compounds, known for its numerous therapeutic properties, including antioxidant, anti-tumoral and antidiabetic effects.
View Article and Find Full Text PDFMachine learning-driven mast cell gene signatures for prognostic and therapeutic prediction in prostate cancer.
Heliyon
August 2024
The First Affiliated Hospital, Xinjiang Medical University, Urumqi, China.
Background: The role of Mast cells has not been thoroughly explored in the context of prostate cancer's (PCA) unpredictable prognosis and mixed immunotherapy outcomes. Our research aims to employs a comprehensive computational methodology to evaluate Mast cell marker gene signatures (MCMGS) derived from a global cohort of 1091 PCA patients. This approach is designed to identify a robust biomarker to assist in prognosis and predicting responses to immunotherapy.
View Article and Find Full Text PDFCD8 T cell‑related KCTD5 contributes to malignant progression and unfavorable clinical outcome of patients with triple‑negative breast cancer.
Mol Med Rep
September 2024
Department of Head and Neck, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi 030013, P.R. China.
Triple‑negative breast cancer (TNBC) is a highly aggressive and heterogeneous subtype of breast cancer that lacks expression of estrogen receptor, progesterone receptor, and HER2, making it more challenging to treat with targeted therapies. The present study aimed to identify CD8+ T cell‑associated genes, which could provide insight into the mechanisms underlying TNBC to facilitate developing novel immunotherapies. TNBC datasets were downloaded from public databases including The Cancer Genome Atlas, Molecular Taxonomy of Breast Cancer International Consortium, and Gene Expression Omnibus.
View Article and Find Full Text PDFCannabidiol Inhibits IgE-Mediated Mast Cell Degranulation and Anaphylaxis in Mice.
Mol Nutr Food Res
February 2024
School of Pharmacy, Jeonbuk National University, Jeonju, 54896, Republic of Korea.
Article Synopsis
- This study explores how cannabidiol (CBD), a compound from the Cannabis plant, affects mast cell degranulation (a key process in allergic reactions) in both human and mouse cells.* -
- Results showed that CBD effectively reduces mast cell degranulation when triggered by antigens, and it does this by working on specific signaling pathways without affecting the overall expression of receptors involved in allergic responses.* -
- The findings suggest that CBD could be a promising treatment for conditions related to mast cell activation, such as allergies and anaphylaxis, since it also reduced allergic reactions in mice.*
Advanced systemic mastocytosis-Revised classification, new drugs and how we treat.
Br J Haematol
February 2024
Division of Hematology, Mayo Clinic, Rochester, Minnesota, USA.
Mastocytosis constitutes the neoplastic proliferation of mast cells and is broadly classified into systemic mastocytosis (SM), cutaneous mastocytosis and mast cell sarcoma. SM is further partitioned into advanced (AdvSM) and non-advanced (SM-non-Adv) subcategories. AdvSM includes aggressive SM (ASM), SM with an associated haematological neoplasm (SM-AHN) and mast cell leukaemia (MCL).
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