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Characteristics of chemically induced liver progenitors derived from a pig model of metabolic dysfunction-associated steatotic liver disease.
PLoS One
December 2024
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Article Synopsis
- The study focused on chemically induced liver progenitors (CLiP) derived from steatotic livers in miniature pigs to assess their potential for future liver disease treatment.
- CLiP from steatotic livers showed a higher ability to proliferate compared to those from healthy livers, but only the normal group demonstrated mature liver cell functionality after re-differentiation.
- Despite the lower production of extracellular vesicles (EVs) in the disease group, the overall findings suggest that CLiP from steatotic livers could be a viable option for cell therapy in liver disease patients.
Transplantation of chemically-induced liver progenitor cells ameliorates hepatic fibrosis in mice with diet-induced nonalcoholic steatohepatitis.
Regen Ther
December 2022
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Unlabelled: Chemically-induced liver progenitors (CLiPs) have promising applications in liver regenerative medicine. We aimed to clarify the efficacy of CLiPs for ameliorating fibrosis in a diet-induced nonalcoholic steatohepatitis rat model, since nonalcoholic fatty liver disease is currently recognized as the most common form of chronic liver disease in developed countries.
Methods: Primary mature hepatocytes were isolated from 7-week-old male Wistar rats.
[Effects of infection on mouse and human uterine natural killer cells].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
April 2022
Department of Pathogen Biology, School of Basic Medical Sciences, Nanjing Medical University, Key Laboratory of Pathogen Biology of Jiangsu Province, Nanjing, Jiangsu 211166, China.
Objective: To examine the effects of infection on the proportion, quantity, differentiation and function of mouse and human uterine natural killer cells (uNK cells), so as to explore the role of uNK cells in abortion of early pregnancy caused by infection.
Methods: Pregnant mice were injected intraperitoneally with tachyzoites on day 6.5 of pregnancy, and the abortion mouse model caused by infections was constructed.
Clinical Validation of a Plasma Donor-derived Cell-free DNA Assay to Detect Allograft Rejection and Injury in Lung Transplant.
Transplant Direct
April 2022
Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University, Columbus, OH.
Background: Lung transplant patients are vulnerable to various forms of allograft injury, whether from acute rejection (AR) (encompassing acute cellular rejection [ACR] and antibody-mediated rejection [AMR]), chronic lung allograft dysfunction (CLAD), or infection (INFXN). Previous research indicates that donor-derived cell-free DNA (dd-cfDNA) is a promising noninvasive biomarker for the detection of AR and allograft injury. Our aim was to validate a clinical plasma dd-cfDNA assay for detection of AR and other allograft injury and to confirm and expand on dd-cfDNA and allograft injury associations observed in previous studies.
View Article and Find Full Text PDFSuccessful induction of human chemically induced liver progenitors with small molecules from damaged liver.
J Gastroenterol
June 2022
Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan.
Background: Human chemically induced liver progenitors (hCLiP) induced by small molecules produced by mature hepatocytes can potentially overcome issues related to hepatocyte transplantation, such as graft rejection or donor shortage. However, to our knowledge, no studies have explored the induction of hCLiP from mature hepatocytes (MHs) in damaged liver, indicated for liver transplantation.
Methods: Liver tissues were collected from surgically resected livers, including damaged livers, of 86 patients at our department, and hepatocytes were isolated using the collagenase perfusion method.
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