Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF00641318 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: The increased incidence of Alzheimer's disease (AD) rate represent an unmet medical need and thus critical for the development of novel molecular therapeutics. Recent work focusing on patients with apoE4 alleles has highlighted the association of brain cholesterol dysregulation with elevated pathological burden and neurodegeneration. These studies have highlighted the importance of the nuclear receptor Liver X receptor (LXR) for developing AD therapies.
View Article and Find Full Text PDFReimagining Male Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia Treatment: A New Approach to First-line Interventional Therapy.
Eur Urol Focus
January 2025
Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Benign prostatic hyperplasia is a prevalent condition leading to male lower urinary tract symptoms (mLUTS), particularly in aging populations. Current management strategies-spanning watchful waiting, pharmaceutical therapy, and surgical interventions such as transurethral resection of the prostate-face significant limitations, including side effects, low adherence, and patient hesitancy toward invasive treatments. First-line interventional therapy (FIT) emerges as a novel paradigm bridging the gap between medications and surgery.
View Article and Find Full Text PDFApproaches to Enhance the Potency of Vaccines in Chickens.
Vaccines (Basel)
November 2024
Avian Influenza and Newcastle Disease Research Group, The Pirbright Institute, Ash Road, Woking GU 24 0NF, UK.
Outbreaks of avian pathogens such as Newcastle disease virus, avian influenza virus, and salmonella have a major impact on economies and food security worldwide. Some pathogens also pose a significant zoonotic potential, especially avian influenza viruses. Vaccination plays a key role in controlling many poultry diseases, and there are many vaccines licenced in the United Kingdom for diseases of poultry caused by viruses, bacteria, and parasites.
View Article and Find Full Text PDFDo Major Pharmacovigilance Databases Support Evidence of Second Trimester NSAID and Third Trimester Paracetamol Fetotoxicity?
Pharmaceuticals (Basel)
November 2024
Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Clinical Pharmacology and Toxicology, Embryotox Center of Clinical Teratology and Drug Safety in Pregnancy, Augustenburger Platz 1, 13353 Berlin, Germany.
Paracetamol and non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used during pregnancy. Due to their fetotoxicity, NSAIDs are contraindicated during the third trimester. There is ongoing controversy about the extent to which NSAIDs may cause cardiovascular and renal impairment in the fetus earlier in the second trimester.
View Article and Find Full Text PDFCiprofloxacin-Induced Encephalopathy.
J Med Cases
January 2025
Department of Internal Medicine, Arrowhead Regional Medical Center, Colton, CA 92324, USA.
Article Synopsis
- Fluoroquinolones (FLQs) are widely used antibiotics for treating infections, but they can have serious side effects, particularly on the central nervous system, in older adults and those with slower medication metabolism.
- These neurotoxic adverse effects can include severe symptoms like seizures and psychosis, and while newer FLQs like levofloxacin are often noted for these issues, even ciprofloxacin can cause them.
- The article highlights the need for healthcare providers to recognize and understand these potential neurotoxic effects, especially in vulnerable populations, through a case study of an 88-year-old with dementia who experienced acute encephalopathy after FLQ treatment.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!