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Neural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment.
Mol Psychiatry
January 2025
Department of Psychiatry, University of Oxford, Oxford, UK.
Cognitive and neural mechanisms underlying bipolar disorder (BD) and its treatment are still poorly understood. Here we examined the role of adaptations in risk-taking using a reward-guided decision-making task. We recruited volunteers with high (n = 40) scores on the Mood Disorder Questionnaire, MDQ, suspected of high risk for bipolar disorder and those with low-risk scores (n = 37).
View Article and Find Full Text PDFDistributed multi-agent reinforcement learning for multi-objective optimal dispatch of microgrids.
ISA Trans
January 2025
School of Control Science and Engineering, Shandong University, Jinan, 250012, China. Electronic address:
The distributed microgrids cooperate to accomplish economic and environmental objectives, which have a vital impact on maintaining the reliable and economic operation of power systems. Therefore a distributed multi-agent reinforcement learning (MARL) algorithm is put forward incorporating the actor-critic architecture, which learns multiple critics for subtasks and utilizes only information from neighbors to find dispatch strategy. Based on our proposed algorithm, multi-objective optimal dispatch problem of microgrids with continuous state changes and power values is dealt with.
View Article and Find Full Text PDFBlood Lactate as a Metabolic Biomarker of Anaerobic Vocal Capacity: A Pilot Study.
J Voice
January 2025
Department of Speech, Language, and Hearing Sciences, Auburn University, Auburn, AL.
Purpose: Blood lactate concentration is commonly used to assess metabolic demand and skeletal muscle training response. The objective of the pilot study was to investigate if a change in blood lactate was detectable in an anaerobically designed vocal demand task vocal capacity anaerobic task (VCAT) and determine if the developed vocal demand task may assess the anaerobic capacity of the voice musculature, like anaerobic power tests commonly used in applied exercise science.
Methods: A prospective repeated measures study quantified blood lactate concentration preVCAT and postVCAT in vocally healthy adults.
Starfield's 4Cs of NCD management in primary healthcare: a conceptual framework development from a case study of 19 countries.
BMJ Glob Health
January 2025
School of Public Health, Imperial College London, London, UK.
Introduction: Faced with a backdrop of an increasing chronic disease burden from an ageing global population compounded with rising healthcare costs, health systems are required to implement cost-effective, safe and equitable care through efficient service delivery models. One approach to achieving this is through Starfield's 4Cs of primary healthcare (PHC), which delineates the key attributes of a high-performing PHC system that upholds the pillars of care coordination, first contact of care, continuity of care and comprehensive care. Therefore, this study aims to explore and elucidate the key themes and subthemes related to and extending beyond Starfield's 4Cs of PHC by integrating findings from a comprehensive literature review and a qualitative study.
View Article and Find Full Text PDFEntrainment of visuomotor responses to target speed during interception.
Neuroscience
January 2025
Departamento de Ciencias Médicas y de la Vida, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán, Mexico; Laboratorio de Conducta Animal, Departamento de Psicología, Centro Universitario de la Ciénega, Universidad de Guadalajara, Ocotlán, Mexico.
Motor actions adapt dynamically to external changes through the brain's ability to predict sensory outcomes and adjust for discrepancies between anticipated and actual sensory inputs. In this study, we investigated how changes in target speed (v) and direction influenced visuomotor responses, focusing on gaze and manual joystick control during an interception task. Participants tracked a moving target with sinusoidal variations in v and directional changes, generating sensory prediction errors and requiring real-time adjustments.
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