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[Next generation sequencing in pediatric bone marrow failure: a valuable tool for accurate diagnosis].
Andes Pediatr
October 2024
Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia.
Unlabelled: Inherited Bone Marrow Failure syndromes account for approximately 25% of cases of aplastic anemia in pediatric patients. Next-generation sequencing (NGS) technologies have allowed the diagnosis of an increasing number of hereditary causes of bone marrow failure.
Objective: To determine the diagnostic yield and clinical concordance of NGS in the diagnosis of a cohort of pediatric patients with bone marrow failure.
Gas-Phase Fluorescence Excitation Experiments on Cryogenically Cold Rhodamine B Cations Linked to Various Amino Acid Esters.
J Am Soc Mass Spectrom
January 2025
Department of Physics and Astronomy, Aarhus University, Aarhus 8000, Denmark.
Förster resonance energy transfer (FRET) is becoming a valuable technique in gas-phase structural biology for identifying local structural motifs and conformations of biological molecules, such as peptides and proteins. This method involves labeling the biomolecule with two dyes, a donor dye and an acceptor dye, that are commonly charged rhodamines. Here we examine how different amino acid (AA) methyl esters linked to the dye via amide linkages can influence the dye transition energy and, consequently, the energy-transfer efficiency, using cryogenic ion fluorescence spectroscopy.
View Article and Find Full Text PDFThree versions of an atopic dermatitis case report written by humans, artificial intelligence, or both: Identification of authorship and preferences.
J Allergy Clin Immunol Glob
February 2025
Big Data Department, Faculdade Israelita de Ciências da Saúde Albert Einstein, São Paulo, Brazil.
Background: The use of artificial intelligence (AI) in scientific writing is rapidly increasing, raising concerns about authorship identification, content quality, and writing efficiency.
Objectives: This study investigates the real-world impact of ChatGPT, a large language model, on those aspects in a simulated publication scenario.
Methods: Forty-eight individuals representing 3 medical expertise levels (medical students, residents, and experts in allergy or dermatology) evaluated 3 blinded versions of an atopic dermatitis case report: one each human written (HUM), AI generated (AI), and combined written (COM).
Predictive Factors of Dental Implant Failure: A Retrospective Study Using Decision Tree Regression.
Cureus
December 2024
Department of Orthodontics, Kothiwal Dental College and Research Centre, Moradabad, IND.
Introduction: Dental implants are routinely used to replace missing teeth. Therefore, the primary aim of the present study was to assess the single-unit implant failure rate over a period of seven years from 2015 to 2021, with a minimum of two years post-implant follow-up. The secondary aim was to identify the risk factors associated with implant failure using machine learning decision tree regression and Kaplan-Meier survival analyses.
View Article and Find Full Text PDFCentral Pancreatectomy as a Surgical Alternative for Parenchyma Preservation.
Cureus
December 2024
Department of Hepatobiliary and Pancreatic Surgery, Pontificia Universidad Católica de Chile, Santiago, CHL.
Pancreatoduodenectomy and distal pancreatectomy are standard treatments for various pancreatic pathologies. These procedures involve radical resection and a significant loss of pancreatic tissue, which can lead to exocrine and/or endocrine pancreatic insufficiency. In selected cases of benign tumors or those with low malignant potential, central pancreatectomy can be performed with acceptable morbidity and mortality rates.
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