Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4615-2007-8_6DOI Listing

Publication Analysis

Top Keywords

aspects one-carbon
4
one-carbon folate
4
folate cycling
4
cycling fluoropyrimidine
4
fluoropyrimidine antifolate
4
antifolate therapy
4
aspects
1
folate
1
cycling
1
fluoropyrimidine
1

Similar Publications

Demands for animal products are projected to increase in the future, and animal production is key to agricultural sustainability and food security; consequently, enhancing ruminant livestock production efficiencies in sustainable ways is a major goal for the livestock industry. Developmental programming is the concept that various stressors, including compromised maternal nutrition during critical developmental windows will result in both short- and long-term changes in the offspring. Ruminant models of developmental programming indicate that compromised maternal nutrition, including global under and over-nutrition, macronutrients, and specific micronutrients, including amino acids (Met and Arg), vitamins (folate, B, and choline), and minerals (sulfur, cobalt, and selenium) can alter offspring outcomes.

View Article and Find Full Text PDF

The developmental integrity and wellbeing of offspring are influenced by events that occur in utero, particularly around the time of conception. While extraneous factors such as environmental temperature and exposure to environmental chemicals can each have a bearing on these events, the epigenetic mechanisms that direct cellular differentiation during early development in ruminants are best described for studies which have investigated the effects of parental nutrition or pregnancy outcomes following assisted reproduction. In this article the case is made that the genetic constitution of an individual directs epigenetic responses to environmental stimuli, and consideration in this regard is also given to the origins of sexual dimorphism and mechanisms of germline intergenerational inheritance.

View Article and Find Full Text PDF

Advanced aspects of acetogens.

Bioresour Technol

December 2024

Institute of Molecular Biology and Biotechnology of Prokaryotes, University of Ulm, Ulm, Germany. Electronic address:

Acetogens are a diverse group of anaerobic bacteria that are capable of carbon dioxide fixation and have for long fascinated scientists due to their unique metabolic prowess. Historically, acetogens have been recognized for their remarkable ability to grow and to produce acetate from different one-carbon sources, including carbon dioxide, carbon monoxide, formate, methanol, and methylated organic compounds. The key metabolic pathway in acetogens responsible for converting these one-carbon sources is ́the Wood-Ljungdahl pathway.

View Article and Find Full Text PDF

[Mechanisms and perspectives of B vitamins associated one carbon metabolism on colorectal cancer risk].

Zhonghua Yu Fang Yi Xue Za Zhi

November 2024

Department of Clinical Laboratory, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai200092, China.

Colorectal cancer (CRC) represents a significant global health challenge as a common malignancy of the digestive tract. The involvement of B vitamins-specifically folic acid (B9), riboflavin (B2), pyridoxine (B6), and cobalamin (B12)-is crucial in metabolic processes by mediating the transfer of one-carbon (1C) units, which plays a fundamental role in cellular functions and tumor growth. 1C metabolism is involved in synthesis of proteins, lipids, nucleic acids, and other cofactors.

View Article and Find Full Text PDF

Fructose metabolism is unregulated in cancers and placentae.

Exp Biol Med (Maywood)

November 2024

Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, United States.

Fructose and lactate are present in high concentrations in uterine luminal fluid, fetal fluids and fetal blood of ungulates and cetaceans, but their roles have been ignored and they have been considered waste products of pregnancy. This review provides evidence for key roles of both fructose and lactate in support of key metabolic pathways required for growth and development of fetal-placental tissues, implantation and placentation. The uterus and placenta of ungulates convert glucose to fructose via the polyol pathway.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!