In giant molecules (greater than 45 S) of HnRNA from pigeon bone marrow and peripheral blood erythroid cells a correlation is demonstrated between the amounts of hairpin-like structures and the sequences transcribed from the DNA repetitions. The same correlation is observed in the greater than 45 S poly(A)+ and poly(A)- subfractions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF00643475 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The coherent structure of the energy cascade in isotropic turbulence.
Sci Rep
January 2025
Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
The energy cascade, i.e. the transfer of kinetic energy from large-scale to small-scale flow motions, has been the cornerstone of turbulence theories and models since the 1940s.
View Article and Find Full Text PDFHow a mixture of microRNA-29a (miR-29a) and microRNA-144 (miR-144) cancer biomarkers interacts with a graphene quantum dot.
J Mol Graph Model
January 2025
Department of Chemistry, Faculty of Science, Kasetsart University, Chatuchak, Bangkok, 10900, Thailand; Center for Advanced Studied in Nanotechnology for Chemical, Food, and Agricultural Industries, KU Institute for Advanced Studies, Kasetsart University, Bangkok, 10900 Thailand. Electronic address:
MicroRNAs (miRNAs) which are small non-coding RNAs have been reported to be potential cancer biomarker. However, it is difficult to extract such short RNA from a sample matrix. New effective strategies are required.
View Article and Find Full Text PDFStructure Derivatization of IgG-Binding Peptides and Analysis of Their Secondary Structure by Circular Dichroism Spectroscopy.
Chem Pharm Bull (Tokyo)
September 2024
Department of Medicinal Chemistry, Tokyo University of Pharmacy and Life Sciences.
Article Synopsis
- * In this research, modifications to specific amino acid positions (Ala5 and Gly9) were shown to significantly influence the secondary structure and binding efficacy of 15-IgBP to immunoglobulin G (IgG).
- * The study identified crucial structural features that can enhance peptide affinity for IgG and discovered new sites for potential attachments in developing antibody-drug conjugates, leading to four peptides with strong binding potential (K = 4.24-5.85 nM).
Structural transitions of a semi-flexible polyampholyte.
J Chem Phys
September 2024
Department of Physics, Indian Institute of Science Education and Research, Bhopal 462066, Madhya Pradesh, India.
Article Synopsis
- Polyampholytes (PAs) are unique charged polymers with both positive and negative charges that affect their structure and dynamics.
- Coarse-grained molecular dynamics simulations reveal that flexible PAs can transition between coil and globule shapes depending on the sequence of charges, with their movement characteristics differing based on charge arrangement.
- For semi-flexible PAs, changes in bending rigidity and electrostatic interactions lead to various shapes, such as globules and toruses, with transitions between these conformations measurable through specific shape factors.
A Novel Dimeric Short Peptide Derived from α-Defensin-Related Rattusin with Improved Antimicrobial and DNA-Binding Activities.
Biomolecules
June 2024
Department of Chemistry, Chonnam National University, Gwangju 61186, Republic of Korea.
Rattusin, an α-defensin-related antimicrobial peptide isolated from the small intestine of rats, has been previously characterized through NMR spectroscopy to elucidate its three-dimensional structure, revealing a C2 homodimeric scaffold stabilized by five disulfide bonds. This study aimed to identify the functional region of rattusin by designing and synthesizing various short analogs, subsequently leading to the development of novel peptide-based antibiotics. The analogs, designated as F1, F2, F3, and F4, were constructed based on the three-dimensional configuration of rattusin, among which F2 is the shortest peptide and exhibited superior antimicrobial efficacy compared to the wild-type peptide.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!