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Metastatic Alveolar Soft Part Sarcoma Presenting as an Adrenal Incidentaloma: A Case Report with Review of Literature.
Int J Surg Pathol
January 2025
Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.
Metastasis of alveolar soft part sarcoma (ASPS) to the adrenal gland is infrequent, with only eight patients reported in the literature. Here we present an ASPS in an adolescent girl presented as a hypervascular adrenal incidentaloma along with a review of the available literature. This study aims to serve as a reference to aid in the pre-operative radiological and histopathological diagnosis of this rare entity.
View Article and Find Full Text PDFRostellularia procumbens (L) Nees. extract attenuates adriamycin-induced nephropathy by maintaining mitochondrial dynamics balance via SIRT1/PGC-1α signaling pathway activation.
J Ethnopharmacol
January 2025
School of Basic Medical Science, Hubei University of Chinese Medicine, Wuhan, 430065, China. Electronic address:
Ethnopharmacological Relevance: Rostellularia procumbens (L) Nees. (R. procumbens) is a classical Chinese herbal medicine that has been used for effective treatment of kidney disease for nearly a thousand years in China.
View Article and Find Full Text PDFExploring Tumor Heterogeneity: Radiogenomic Assessment of ADFP in Low WHO/ISUP Grade Clear Cell Renal Cell Carcinoma.
Cancers (Basel)
September 2024
Research Unit of Radiology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy.
This study aimed to investigate the association between metabolic lipid computed tomography (CT) features and adipose differentiation-related protein (ADFP) expression in clear cell renal cell carcinoma (ccRCC), providing insights into non-invasive methods for assessing ADFP expression and tumor characteristics. This study utilized data from The Cancer Genome Atlas and the Cancer Imaging Archive to analyze genetic alterations and imaging characteristics in ccRCC patients. Tumoral Hounsfield units (HU) analysis and quantification of abdominal adipose tissue compartments were performed using CT images.
View Article and Find Full Text PDFMitochondrial GPX4 acetylation is involved in cadmium-induced renal cell ferroptosis.
Redox Biol
July 2024
Department of Urology, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China. Electronic address:
Article Synopsis
- Environmental stressors, like cadmium (Cd), significantly contribute to acute kidney injury (AKI) by inducing ferroptosis in renal cells.
- Exposure to Cd disrupts the arachidonic acid metabolic pathway and increases harmful lipid peroxidation markers in mice kidneys, indicating oxidative stress.
- Reduced levels of SIRT3 lead to increased acetylation of GPX4, exacerbating ferroptosis, but treatment with nicotinamide mononucleotide (NMN) helps mitigate these effects.
Ultrastructure expansion microscopy (U-ExM) of mouse and human kidneys for analysis of subcellular structures.
Cytoskeleton (Hoboken)
November 2024
Department of Medicine, Washington University, St. Louis, Missouri, USA.
Ultrastructure expansion microscopy (U-ExM) involves the physical magnification of specimens embedded in hydrogels, which allows for super-resolution imaging of subcellular structures using a conventional diffraction-limited microscope. Methods for expansion microscopy exist for several organisms, organs, and cell types, and used to analyze cellular organelles and substructures in nanoscale resolution. Here, we describe a simple step-by-step U-ExM protocol for the expansion, immunostaining, imaging, and analysis of cytoskeletal and organellar structures in kidney tissue.
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