It has been shown that the unsaturated free fatty acids evoke calcium release from sarcoplasmic reticulum vesicles of the rabbit skeletal muscle by means of the increase of permeability of terminal cisternae Ca-release channel. The effect of free acids was the same as the effects of Ca-channel activators, caffeine and silver ions, and was blocked by ruthenium red and procaine. Saturated fatty acids did not stimulate the release of Ca from reticulum.
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