This contribution describes the software system KAMEDIN (Kooperatives Arbeiten und MEdizinische Diagnostik auf Innovativen Netzen) that is designed as an ISDN based computer supported cooperative work (CSCW) tool for usage in medical diagnostics. Medical image data from various sources (for example CT and MR) can be interchanged and analyzed in bilateral teleconferences via ISDN. During a cooperative session, user interactions for image processing etc., are synchronized and performed on both workstations, Features like telepointing, remote control, and audio connection enhance communication quality. With ISDN as a transmission line, widespread availability and low communication costs are achieved. Further, automatic tissue labeling in intracranial MR data can be invoked. For this purpose, artificial neural network classifiers such as multilayer perceptron and Kohenen feature map are integrated. Classification results can be viewed as 3D-reconstructions.
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Cureus
September 2024
Community and Family Medicine, All India Institutes of Medical Sciences, Madurai, Madurai, IND.
Background Chronic kidney disease (CKD) is an emerging public health problem in India. Pulmonary hypertension (PH) is an overlooked cardiovascular complication of CKD. This study aimed to estimate the burden of PH among CKD patients undergoing hemodialysis in a selected tertiary care hospital.
View Article and Find Full Text PDFBMC Cardiovasc Disord
May 2024
College of Pharmacy, University of Michigan, Ann Arbor, MI, USA.
Background: Despite the strong evidence supporting guideline-directed medical therapy (GDMT) in patients with heart failure with reduced ejection fraction (HFrEF), prescription rates in clinical practice are still lacking.
Methods: A survey containing 20 clinical vignettes of patients with HFrEF was answered by a national sample of 127 cardiologists and 68 internal/family medicine physicians. Each vignette had 4-5 options for adjusting GDMT and the option to make no medication changes.
Headache
March 2024
Neuro-Dol, Inserm, CHU Clermont-Ferrand, Université Clermont Auvergne, Clermont-Ferrand, France.
Objective: The aim of this study was to test whether a combination of sumatriptan with dual enkephalinase inhibitor PL37 would result in an additive or a synergistic effect.
Background: Combination treatment is frequently used to improve the therapeutic efficacy of drugs. The co-administration of two drugs may result in efficacy at lower doses than those needed for either drug alone, thus minimizing side effects.
Medicina (Kaunas)
December 2023
Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan.
: An interventional diagnostic procedure (IDP), including intracoronary acetylcholine (ACh) provocation and coronary physiological testing, is recommended as an invasive diagnostic standard for patients suspected of ischemia with no obstructive coronary arteries (INOCA). Recent guidelines suggest Thrombolysis In Myocardial Infarction frame count (TFC) as an alternative to wire-based coronary physiological indices for diagnosing coronary microvascular dysfunction. We evaluated trajectories of TFC during IDP and the impact of ACh provocation on TFC.
View Article and Find Full Text PDFAsian J Pharm Sci
January 2022
School of Pharmacy, North China University of Science and Technology, Tangshan 063000, China.
To explore the structure-activity connections of amphiphilic permeation enhancers containing the length of the hydrophobic chains as well as the properties of the polar head, -acylgeraniol and -acylnerol derivatives were synthesized from geraniol/nerol (-isomer of geraniol) and pharmaceutical excipient acids in this research. Their promotion of the percutaneous absorption of three drugs as the model, flurbiprofen (FP), isosorbide dinitrate (ISDN) and donepezil (DNP), which were selected based on their physicochemical properties, was tested by skin penetration and . Molecular simulation, ATR-FTIR, CLSM and histological observation were implement to evaluate the mode of action of the enhancers.
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