We describe a family with severe thrombosis of early onset in two siblings and in their father. Low levels of TFPI were detected in the two siblings (50% and 45% respectively) but their parents have normal TFPI levels. All other hemostatic proteins associated with thrombophilia, as well as blood lipids were within the normal range. The release of TFPI, after heparin administration, was proportionally reduced in the two siblings as compared with controls. The study of this family does not permit to conclude that low levels of TFPI are responsible for their thrombophilia. In the future the study of more families with similar characteristics may allow to know the inheritance of TFPI and whether there is a causal relationship between low levels of TFPI and thrombosis.
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http://dx.doi.org/10.1016/0049-3848(95)00193-u | DOI Listing |
JAMA Netw Open
January 2025
Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Importance: High-quality colonoscopy reduces the risks of colorectal cancer by increasing the adenoma detection rate. Routine use of an automatic quality control system (AQCS) to assist in colorectal adenoma detection should be considered.
Objective: To evaluate the effect of an AQCS on the adenoma detection rate among colonoscopists who were moderate- and low-level detectors during routine colonoscopy.
Nurs Res
January 2025
School of Nursing, The University of Texas at Austin.
Background: People with type 2 diabetes mellitus (T2DM) commonly report a higher fatigue intensity than the general population. However, effective fatigue management is lacking because little is known about other fatigue characteristics, including timing, distress, and quality, as well as the potential fatigue subtypes experienced in people with T2DM.
Objective: To describe fatigue intensity, timing, distress, and quality, and identify fatigue subtypes in people with T2DM.
ACS Nano
January 2025
Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 9017 - CIIL - Center for Infection and Immunity of Lille, F-59000 Lille, France.
Atomic force microscopy (AFM) has reached a significant level of maturity in biology, demonstrated by the diversity of modes for obtaining not only topographical images but also insightful mechanical and adhesion data by performing force measurements on delicate samples with a controlled environment (e.g., liquid, temperature, pH).
View Article and Find Full Text PDFThis study tested the possibility that the four facets of the Psychopathy Checklist-Revised/Screening Version (PCL-R/SV) serve as bipolar constructs in predicting future criminal justice outcomes. Organizing scores on the four facets (Interpersonal, Affective, Lifestyle, and Antisocial) into three categories-that is, lowest 25% of cases (best category), highest 25% of cases (worst category), and middle 50% of cases (intermediate category)-we tested bipolarity by crossing the three categories with a dichotomized crime/violence outcome and calculating both promotive (best category vs. worst + intermediate categories) and risk (worst category vs.
View Article and Find Full Text PDFMed Biol Eng Comput
January 2025
College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, 110169, China.
Accurately and swiftly segmenting breast tumors is significant for cancer diagnosis and treatment. Ultrasound imaging stands as one of the widely employed methods in clinical practice. However, due to challenges such as low contrast, blurred boundaries, and prevalent shadows in ultrasound images, tumor segmentation remains a daunting task.
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