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A lever hypothesis for Synaptotagmin-1 action in neurotransmitter release.
Proc Natl Acad Sci U S A
January 2025
Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
Neurotransmitter release is triggered in microseconds by Ca-binding to the Synaptotagmin-1 C-domains and by SNARE complexes that form four-helix bundles between synaptic vesicles and plasma membranes, but the coupling mechanism between Ca-sensing and membrane fusion is unknown. Release requires extension of SNARE helices into juxtamembrane linkers that precede transmembrane regions (linker zippering) and binding of the Synaptotagmin-1 CB domain to SNARE complexes through a "primary interface" comprising two regions (I and II). The Synaptotagmin-1 Ca-binding loops were believed to accelerate membrane fusion by inducing membrane curvature, perturbing lipid bilayers, or helping bridge the membranes, but SNARE complex binding through the primary interface orients the Ca-binding loops away from the fusion site, hindering these putative activities.
View Article and Find Full Text PDFFlexible disk ultramicroelectrode: Facile preparation and high-resolution scanning electrochemical microscopy imaging.
Anal Chim Acta
January 2025
State Key Laboratory of Electroanalytical Chemistry, Jilin Province Key Laboratory of Low Carbon Chemical Power, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, 230026, Anhui, China. Electronic address:
Background: Scanning electrochemical microscopy (SECM) is a kind of scanning probe technology that enables the obtainment of surface morphology and electrochemical information by recording changes in Faraday current triggered by the movement of probe.
Results: In this work, flexible disk ultramicroelectrode (UME) with highly repeatable geometry are fabricated through a simple and universal strategy that involves vacuum pulling the glass capillaries inserted with platinum wire (gold wire, carbon fiber, etc.), followed by a rapidly heated sealing and polishing process.
Primary Headache Attributed to External Compression or Traction to the Head: A Narrative Review.
Brain Behav
January 2025
University Clinic and Outpatient Clinic for Neurology, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany.
Background: The aim of this review is to synthesize the existing knowledge regarding headaches attributed to external physical stimuli, as classified by the ICHD-3 (Group 4.6). Two forms can be distinguished in this group: (1) headache attributed to external compression and (2) headache attributed to external traction.
View Article and Find Full Text PDFEscape of etiolated hypocotyls of cotton () from the unilateral high intensity blue light after being pulled out from the soil.
Funct Plant Biol
December 2024
National Key Laboratory of Cotton Bio-Breeding and Integrated Utilization, School of Life Sciences, Henan University, Kaifeng 475004, China.
Plant stems grow towards the incident light in response to unilateral blue light to optimize photosynthesis. However, our findings reveal that unilateral high-intensity blue light (HBL) triggers backlit lodging in etiolated cotton (Gossypium hirsutum ) hypocotyls when they are pulled approximately 1.5cm from the soil.
View Article and Find Full Text PDFConstruction of bilayer biomimetic periosteum based on SLA-3D printing for bone regeneration.
Colloids Surf B Biointerfaces
February 2025
Center for Advanced Jet Engineering Technologies (CaJET), School of Mechanical Engineering, Shandong University, Jinan 250061, China; Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Ministry of Education, Shandong University, China; National Demonstration Center for Experimental Mechanical Engineering Education (Shandong University), China; Additive Manufacturing Research Center of Shandong University of National Engineering Research Center of Rapid Manufacturing, Jinan 250061, China.
An ideal biomimetic periosteum should have excellent biocompatibility to promote osteoclast adhesion and improve osseointegration, which is significant in promoting bone regeneration. In this work, a bionic artificial periosteum printed by the SLA-3D printing was prepared, consisting of a poly (ethylene glycol) diacrylate (PEGDA)/chitosan/tricalcium phosphate (TCP) fibrous layer and a gelatin methacryloyl (GelMA)/ammonium molybdate (Mo) cambium layer. Distinct surface characteristics were achieved on both sides of the biomimetic periosteum.
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