The effects of endothelin-1 (ET-1) and endothelin-3 (ET-3) were investigated on carbachol-contracted guinea-pig trachea. ET-1 and ET-3 induced a dose-dependent relaxation of the precontracted preparations. ET-1-induced relaxation was attenuated by hemoglobin and methylene blue. By contrast, ET-3-induced relaxation was not affected by hemoglobin or methylene blue. The large conductance Ca(2+)-activated K(+)-channel blocker charybdotoxin antagonized ET-1- and ET-3-induced relaxations. These results show that charybdotoxin-sensitive K+ channels are involved in both ET-1 and ET-3 relaxant activities, whereas the nitric oxide pathway is involved only in ET-1 relaxant effects.
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The Effect of Alkyl Substituents on the Formation and Structure of Homochiral (*,*)-[RGa(-OCH(Me)COR')] Species-Towards the Factors Controlling the Stereoselectivity of Dialkylgallium Alkoxides in the Ring-Opening Polymerization of -Lactide.
Molecules
January 2025
Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3, 00-664 Warsaw, Poland.
Building on our previous studies, which have demonstrated that homochiral propagating species-(*,*)-[MeGa(-OCH(Me)COR)]-were crucial for the heteroselectivity of [MeGa(-OCH(Me)COMe)] in the ring-opening polymerization (ROP) of racemic lactide (-LA), we have investigated the effect of alkyl groups on the structure and catalytic properties of dialkylgallium alkoxides in the ROP of -LA. Therefore, we have isolated and characterized the -[RGa(-OCH(Me)COMe] (R = Et (), Pr () and -[RGa(-OCH(Me)CHN] (R = Et (), Pr ()) complexes, to demonstrate the effect of alkyl groups on the chiral recognition induced the formation of the respective homochiaral species-(*,*)-[RGa(-OCH(Me)COMe)] and (*,*)-[RGa(-OCH(Me)CHN]. Moreover, we have investigated the structure of (,)-[RGa(-OCH(Me)COMe] (R = Et ((,)-, R = Pr ((,)-,) and their catalytic activity in the ROP of -LA.
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Teagasc, Animal and Grassland Research and Innovation Centre, Moorepark, Fermoy, Co. Cork P61 C996, Ireland. Electronic address:
The aim of this study was to characterize the incidence and timing of pregnancy loss from service event (timed artificial insemination or timed embryo transfer) to parturition. Lactating Holstein-Friesian cows were randomly assigned to receive either AI (n = 243) or embryo transfer (ET, n = 863) with a fresh or frozen in vitro-produced blastocyst derived from oocytes collected from the ovaries of elite dairy donors (n = 14 Holstein-Friesian and n = 8 Jersey) and elite beef donors (n = 21 Angus) using transvaginal ovum pick-up. In addition, oocytes were collected from the ovaries of beef heifers of known pedigree following slaughter at a commercial abattoir (n = 119).
View Article and Find Full Text PDFOral administration of a dual ET/ET receptor antagonist promotes neuroprotection in a rodent model of glaucoma.
Mol Vis
October 2022
University of North Texas Health Science Center, Pharmacology and Neuroscience, North Texas Eye Research Institute, Fort Worth, TX.
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Chemosphere
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The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA. Electronic address:
Short-term increases in particulate matter (PM) are associated with heightened morbidity and mortality from cardiovascular causes. Inhalation of PM is known to increase endothelin (ET)-1 levels. Yet, less is known about particle composition-related changes at the molecular level including the endothelinergic system and relationship with cardiovascular function changes.
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