From the clinical point of view, the diagnosis of "hibernating myocardium" is of predominant importance in patients with LV-dysfunction, because a prediction of a possible functional recovery allows to determine risk and outcome of an intervention. Alone or in combination, thalliumscintigraphy with reinjection and dobutamine echocardiography are suitable to detect "hibernating myocardium". In addition, morphological investigations of biopsies taken from hibernating regions permit the evaluation of structural changes. The spectrum of alterations is wide and at a certain degree of severity they are irreversible. The relation between clinical and morphological results provides further insight into the degree of injury and of functional recovery after adequate revascularization.
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Cureus
November 2024
Internal Medicine Department, Shalamar Hospital, Lahore, PAK.
Introduction: Acute anterior wall myocardial infarction (AWMI), when presenting with ST-segment elevation on an electrocardiogram (ECG), represents a form of ST-elevation myocardial infarction (STEMI) caused by a significant reduction in coronary blood flow to the heart muscle. The shape of the ST-segment elevation, whether it is concave, convex, or straight, has been associated with different levels of left ventricular ejection fraction (LVEF), which is an important indicator of cardiac function and prognosis.
Objective: To investigate the relationship between the type of ST-segment elevation on ECG and LVEF measured 48 hours after the onset of myocardial infarction in patients with AWMI.
Medicine (Baltimore)
October 2024
Department of Nuclear Medicine, TEDA International Cardiovascular Hospital, Tianjin University, Tianjin, P.R. China.
The influence of computed tomography attenuation correction (CTAC) on the accuracy of diagnosing viable myocardium using Tc-99m-MIBI dedicated cardiac cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) combined with F-18-FDG Positron Emission Tomography/Computed Tomography (PET/CT) metabolic imaging, compared with conventional SPECT MPI, remains to be fully elucidated. To evaluate the impact of CTAC on the accuracy of diagnosing viable myocardium using Tc-99m-MIBI dedicated cardiac CZT SPECT MPI combined with F-18-FDG PET/CT, compared to conventional SPECT MPI. 193 patients underwent CZT SPECT and F-18-FDG PET/CT imaging, while 39 patients underwent conventional SPECT and F-18-FDG PET/CT imaging, with both groups utilizing CT for attenuation correction.
View Article and Find Full Text PDFCureus
September 2024
Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, IND.
Background To assess the feasibility of a machine learning (ML) approach using radiomics features of perfusion defects on rest myocardial perfusion imaging (MPI) to detect the presence of hibernating myocardium. Methodology Data of patients who underwent 99mTc-sestamibi MPI and 18F-FDG PET/CT for myocardial viability assessment were retrieved. Rest MPI data were processed on ECToolbox, and polar maps were saved using the NFile PMap tool.
View Article and Find Full Text PDFJ Coll Physicians Surg Pak
October 2024
Department of Radiology, The Aga Khan University Hospital, Karachi, Pakistan.
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View Article and Find Full Text PDFArab J Urol
March 2024
Department of Urology, Takamatsu Red Cross Hospital, Takamatsu, Kagawa, Japan.
Objective: Chronic ischemia-related cavernous dysfunction is considered irreversible. However, in certain patients, cavernous function appears to recover with penile revascularization. In this study, we investigated a potential cavernous dysfunction reversibility from a clinical perspective.
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