In recent years researchers have devised a number of methods to detect patients who purposely exert low effort during grip evaluations. This study further defines the five-rung grip test introduced by Stokes and subsequently challenged by Niebuhr and Marion. New data are presented on the rapid exchange grip test. Data were collected on four groups of subjects (sincere normals, normals asked to feign weak grip, patients thought to be sincere, and patients suspected of low effort) using both tests. In calculating the standard deviation of the plotted line of the five-rung grip test, group membership (sincere or low effort) can be predicted. No statistical difference between peak scores on five-rung and rapid exchange grip tests in sincere subjects was found. A statistical difference between peak scores in the low-effort groups was shown. A model has been developed that can be used to categorize patients into low effort or sincere groups.
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http://dx.doi.org/10.1016/S0363-5023(05)80158-3 | DOI Listing |
Am J Manag Care
January 2025
RAND, 1776 Main St, Santa Monica, CA 90401. Email:
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Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, Canada.
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Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia.
Despite significant global reductions in cases of pneumonia during the last 3 decades, pneumonia remains the leading cause of post-neonatal mortality in children aged <5 years. Beyond the immediate disease burden it imposes, pneumonia contributes to long-term morbidity, including lung function deficits and bronchiectasis. Viruses are the most common cause of childhood pneumonia, but bacteria also play a crucial role.
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John Ochsner Heart and Vascular Institute, Ochsner Clinical School University of Queensland School of Medicine, New Orleans, LA, USA.
Purpose Of Review: To provide a narrative overview of trends and disparities in the cardiometabolic profiles of U.S. adults by synthesizing findings from nationally representative studies conducted between 1999 and 2020.
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Automation, Digital and Learning Solutions, Cytiva, Karlsruhe, Germany.
Mechanistic modeling of chromatographic steps is an effective tool in biopharma process development that enhances process understanding and accelerates optimization efforts and subsequent risk assessment. A relatively new model for ion exchange chromatography is the colloidal particle adsorption (CPA) formalism, which promises improved separation of material and molecule-specific parameters. This case study demonstrates a straightforward CPA modeling workflow to describe an ion exchange chromatography polishing step of a knobs-into-holes construct bispecific antibody molecule.
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