Neuropharmacological effects (Spontaneous locomotor activity, forced locomotor activity and anticonvulsant activity) of invermectin were studied at 400, 800 and 1600 micrograms/kg (administered, subcutaneously). Spontaneous locomotor activity was reduced at all the dose levels but forced locomotor activity was slightly reduced at 800 and 1600 micrograms/kg. The drug did not exhibit any anticonvulsant potential at any of the dose levels studied.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The effects of xylazine on locomotion and motor behaviour in a planarian model.
Behav Pharmacol
January 2025
Department of Psychology, Massachusetts College of Liberal Arts, Massachusetts, USA.
In recent years, the recreational use of xylazine has increased dramatically in the USA. Although xylazine has been used as an anesthetic in veterinary medicine for decades, little is known about its behavioral effects. We took advantage of the planarian's innate negative phototaxis, the reliable movement from the light side to the dark side of a Petri dish, to explore the organism's suitability as an animal model for investigating the preclinical pharmacology of xylazine.
View Article and Find Full Text PDFIntegrated in silico and in vitro exploration of the anti-VEGFR-2 activities of a semisynthetic xanthine alkaloid inhibiting breast cancer.
PLoS One
January 2025
Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt.
This study presents T-1-NBAB, a new compound derived from the natural xanthine alkaloid theobromine, aimed at inhibiting VEGFR-2, a crucial protein in angiogenesis. T-1-NBAB's potential to interacts with and inhibit the VEGFR-2 was indicated using in silico techniques like molecular docking, MD simulations, MM-GBSA, PLIP, essential dynamics, and bi-dimensional projection experiments. DFT experiments was utilized also to study the structural and electrostatic properties of T-1-NBAB.
View Article and Find Full Text PDFEffects of treadmill running on anxiety- and craniofacial pain-like behaviors with histone H3 acetylation in the brain of mice subjected to social defeat stress.
PLoS One
January 2025
Division of Oral Physiology, Faculty of Dentistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
This study examined the effects of treadmill running (TR) regimens on craniofacial pain- and anxiety-like behaviors, as well as their effects on neural changes in specific brain regions of male mice subjected to repeated social defeat stress (SDS) for 10 days. Behavioral and immunohistochemical experiments were conducted to evaluate the impact of TR regimens on SDS-related those behaviors, as well as epigenetic and neural activity markers in the anterior cingulate cortex (ACC), insular cortex (IC), rostral ventromedial medulla (RVM), and cervical spinal dorsal horn (C2). Behavioral responses were quantified using multiple tests, while immunohistochemistry measured histone H3 acetylation, histone deacetylases (HDAC1, HDAC2), and neural activity markers (FosB and phosphorylated cAMP response element-binding protein (pCREB).
View Article and Find Full Text PDFCombining radio-telemetry and radar measurements to test optimal foraging in an aerial insectivore bird.
Elife
January 2025
Department of Evolutionary and Environmental Biology and Institute of Evolution, University of Haifa, Haifa, Israel.
Optimal foraging theory posits that foragers adjust their movements based on prey abundance to optimize food intake. While extensively studied in terrestrial and marine environments, aerial foraging has remained relatively unexplored due to technological limitations. This study, uniquely combining BirdScan-MR1 radar and the Advanced Tracking and Localization of Animals in Real-Life Systems biotelemetry system, investigates the foraging dynamics of Little Swifts () in response to insect movements over Israel's Hula Valley.
View Article and Find Full Text PDFImportance of the assessment of knee joint function after a stroke.
Acta Bioeng Biomech
September 2024
Department of Rehabilitation and Physiotherapy, Poznan University of Medical Sciences, Poznań, Poland.
: This study aimed to assess knee joint function in post-stroke patients using wireless motion sensors and functional tests. This type of evaluation may be important for improving gait quality. : The study included 25 post-stroke patients (age 53.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!