The concentration-dependence of the inhibition of whole-cell hydrogen formation by oxygen has been measured in the trichomonads Trichomonas vaginalis and Tritrichomonas foetus, and compared with the oxygen inhibition of the in situ hydrogenase activity as measured by a tritium exchange assay. The inhibition profiles closely paralleled each other, suggesting that hydrogenase is the primary site of inhibition of anaerobic fermentative metabolism. In addition the inhibition profile for isolated hydrogenosomes was measured and shown to be similar to that for whole organisms. Ascorbate peroxidase was shown to be present in both organisms whereas catalase was confirmed to be present only in Tritr. foetus. The kinetic parameters of both enzymes were measured and their respective roles in oxygen protection discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1099/13500872-142-1-207 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Systematic Review of Vaccine Strategies Against Tritrichomonas foetus Infection in Cattle: Insights, Challenges, and Prospects.
Parasite Immunol
January 2025
The University of Queensland, Queensland Alliance for Agriculture & Food Innovation, Centre for Animal Science, St Lucia, Queensland, Australia.
Tritrichomonas foetus is a protozoan parasite that causes bovine trichomonosis (also referred to as trichomoniasis) resulting in substantial economic loss in extensive grazing systems. The parasite colonises the reproductive tracts of both male and female cattle, being asymptomatic in males but causing early reproductive failure in infected females. This systematic review aimed to examine research manuscripts describing the development of T.
View Article and Find Full Text PDFBovine trichomoniasis: A hidden threat to reproductive efficiency.
Open Vet J
November 2024
Research Center for Preclinical and Clinical Medicine, National Research and Innovation Agency (BRIN), Bogor, Indonesia.
Bovine trichomoniasis is a reproductive illness that affects cattle causing pyometra, early to mid-pregnancy miscarriages, and lower birth rates. is a flagellated protozoan which first discovered in France in 1888 and composts three phases during its lifecycle including trophozoite, cyst, and pseudocyst. In addition, several factors contributed to the prevalence of trichomoniasis and fall into three categories are management, cow, and bull-related factors.
View Article and Find Full Text PDFTranscriptome and Evolutionary Analysis of Pseudotrichomonas keilini, a Free-Living Anaerobic Eukaryote.
Genome Biol Evol
December 2024
School of Biological Sciences, University of Bristol, Bristol BS8 1TH, UK.
The early evolution of eukaryotes and their adaptations to low-oxygen environments are fascinating open questions in biology. Genome-scale data from novel eukaryotes, and particularly from free-living lineages, are the key to answering these questions. The Parabasalia are a major group of anaerobic eukaryotes that form the most speciose lineage of Metamonada.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to check for the presence of Tritrichomonas foetus in male reproductive tissues of bulls that tested positive and analyzed how post mortem tissue acidity affects testing accuracy.
- Eight bulls were euthanized, and samples from their testicles, epididymis, and accessory sex glands were collected; however, T foetus was not found in any of these tissues.
- Researchers found that as the pH of the penis and prepuce decreased after death, the cycle threshold values increased, indicating that pH changes could influence the effectiveness of detecting genetic material over time.
Vaginal Tritrichomonas foetus infection in mice as an in vivo model for drug development against Trichomonas vaginalis.
PLoS One
October 2024
Department of Medicine, University of California San Diego, La Jolla, California, United States of America.
Article Synopsis
- Trichomonas vaginalis causes trichomoniasis, a widespread STD that affects over a hundred million people, and resistance to common treatments like metronidazole is increasing.
- The study explored using Tritrichomonas foetus, a related parasite, as a better animal model for testing new treatments since it caused reliable infections in mice, unlike T. vaginalis.
- Findings showed that while some drugs had similar effectiveness on both parasites, proteasome inhibitors were less effective on T. foetus, suggesting the need for targeted drug development and further understanding of genetic differences between the two organisms.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!