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Single cytoplasmic dynein molecule movements: characterization and comparison with kinesin. | LitMetric

Single cytoplasmic dynein molecule movements: characterization and comparison with kinesin.

Biophys J

Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA.

Published: November 1995

AI Article Synopsis

Article Abstract

Cytoplasmic dynein is a major microtubule motor for minus-end directed movements including retrograde axonal transport. To better understand the mechanism by which cytoplasmic dynein converts ATP energy into motility, we have analyzed the nanometer-level displacements of latex beads coated with low numbers of cytoplasmic dynein molecules. Cytoplasmic dynein-coated beads exhibited greater lateral movements among microtubule protofilaments (ave. 5.1 times/microns of displacement) compared with kinesin (ave. 0.9 times/micron). In addition, dynein moved rearward up to 100 nm over several hundred milliseconds, often in correlation with off-axis movements from one protofilament to another. We suggest that single molecules of cytoplasmic dynein move the beads because 1) there is a linear dependence of bead motility on dynein/bead ratio, 2) the binding of beads to microtubules studied by laser tweezers is best fit by a first-order Poisson, and 3) the run length histogram of dynein beads follows a first-order decay. At the cellular level, the greater disorder of cytoplasmic dynein movements may facilitate transport by decreasing the duration of collisions between kinesin and cytoplasmic dynein-powered vesicles.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236434PMC
http://dx.doi.org/10.1016/S0006-3495(95)80071-8DOI Listing

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