Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/nm0296-130 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Low expression of Frataxin might contribute to diabetic peripheral neuropathy in a mouse model.
Biochem Biophys Res Commun
January 2025
Yancheng Clinical College, Xuzhou Medical University, Yancheng, 224000, PR China. Electronic address:
Diabetes is one of the most prevalent metabolic disorders, and its incidence has been experiencing a steady annual rise in recent years. Diabetic peripheral neuropathy (DPN) represents the most frequent adverse complication, exerting a profound impact on the quality of life for those suffering from diabetes. The etiology of DPN is complex, including impaired mitochondrial function.
View Article and Find Full Text PDFNesfatin-1 is involved in hyperbaric oxygen-mediated therapeutic effects in high fat diet-induced hyperphagia in mice.
Peptides
January 2025
Department of Special Medicine, School of Basic Medicine, Qingdao University, Qingdao 266000, China. Electronic address:
Article Synopsis
- Obesity is a significant global health concern, and safe treatments are needed.
- The study explored hyperbaric oxygen (HBO) therapy as a potential method to reduce overeating and high energy intake in mice fed a high-fat diet.
- Results showed that HBO treatment decreased food intake and altered brain activity linked to hunger regulation, potentially involving the nesfatin-1 peptide and the melanocortin system.
Leptin deficiency leads to nerve degeneration and impairs axon remyelination by inducing Schwann cell apoptosis and demyelination in type 2 diabetic peripheral neuropathy in rats.
Neurochem Int
January 2025
Division of Plastic and Reconstructive Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan; Department of Physiology, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan. Electronic address:
Diabetic peripheral neuropathy, characterized by symptoms such as paresthesia, neuropathic pain, and potential lower limb amputation, poses significant clinical management challenges. Recent studies suggest that chronic hyperglycemia-induced Schwann cells (SCs) apoptosis contributes to neurodegeneration and impaired nerve regeneration, but the detailed mechanisms are still unknown. Our study investigated a mixed-sex type 2 diabetes mellitus (T2DM) rat model using leptin knockout (KO) to simulate obesity and diabetes-related conditions.
View Article and Find Full Text PDFInfluence of Lactation Stage on Content of Neurotrophic Factors, Leptin, and Insulin in Human Milk.
Molecules
October 2024
Department of Physiology and Toxicology, Faculty of Biological Sciences, Kazimierz Wielki University, Chodkiewicza 30 St., 85-064 Bydgoszcz, Poland.
Human milk comprehensively meets the nutritional needs of a child, providing not only structural and energy components but also various bioactive factors. Among these, neurotrophic factors and hormones involved in metabolic processes deserve special attention. Studies using enzyme-linked immunosorbent assays compared the content of neurotrophic factors-CNTF, NT-3, and NGF-and hormones, leptin and insulin, in two groups of breast milk samples: early lactation (1-3 months) and extended lactation (>6 months, up to 12 months).
View Article and Find Full Text PDFInter-Organ Communication Involved in Brown Adipose Tissue Thermogenesis.
Adv Exp Med Biol
September 2024
Department of Diabetes, Metabolism and Endocrinology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Brown and beige adipocytes produce heat from substrates such as fatty acids and glucose. Such heat productions occur in response to various stimuli and are called adaptive non-shivering thermogenesis. This review introduces mechanisms known to regulate brown and beige adipocyte thermogenesis.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!