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Reconstructing skeletal homeostasis through allogeneic hematopoietic stem cell transplantation in myelofibrosis.
Nat Commun
January 2025
Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Myeloproliferative neoplasm-associated myelofibrosis is a clonal stem cell process characterized by pronounced bone marrow fibrosis associated with extramedullary hematopoiesis and splenomegaly. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) represents the only curative treatment leading to bone marrow fibrosis regression. Here we provide an in-depth skeletal characterization of myelofibrosis patients before and after allo-HSCT utilizing clinical high-resolution imaging, laboratory analyses, and bone biopsy studies.
View Article and Find Full Text PDFLong-term Postural Stability Changes After Correction of Spinal Deformity: A prospective, controlled pilot study.
Spine (Phila Pa 1976)
January 2025
Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Study Design: Prospective cohort study.
Objective: This study aimed to investigate the durability of postural stability after ASD correction surgery and its' association with clinical outcomes.
Summary Of Background Data: The prevalence of symptomatic adult spinal deformity (ASD) necessitates surgical intervention, aiming to correct global spinal balance and spinopelvic parameters.
Return to work after lumbar microdiskectomy - a systematic review and meta-analysis.
Spine (Phila Pa 1976)
January 2025
Department of Physical and Rehabilitation Medicine, Turku University Hospital and University of Turku, Turku, Finland.
Study Design: Systematic review and meta-analysis.
Objective: To investigate evidence on the prevalence and timeline of RTW after lumbar microdiskectomy.
Summary Of Background Data: While lumbar microdiskectomy is a widely used and well-studied procedure, there is lack of evidence on the postoperative prevalence and schedule of return to work after this type of surgery.
Change in spinopelvic mobility 3 months after THA using a direct anterior approach.
Orthop Traumatol Surg Res
January 2025
Orthopaedic Department, Croix St Simon Hospital 125 rue d'Avron, 75020 Paris, France.
Introduction: Spinopelvic kinematics, reflected by the change in spinopelvic tilt (ΔSPT) from a standing position to a flexed seated position, has been associated with the risk of prosthetic impingement and hip dislocation. Some studies have suggested changes in spinopelvic mobility after total hip arthroplasty (THA), but none have explored changes in mobility in the first three months following THA using a direct anterior approach.
Hypothesis: Our hypothesis was that changes in spinopelvic mobility occur in the first 3 months postoperatively, leading to increased hip mobility and increased spinopelvic kinematic abnormalities.
Development of a patient decision aid for people with chronic low back pain and degenerative disc disease considering lumbar fusion: A mixed-methods study.
Musculoskelet Sci Pract
January 2025
Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Australia; Institute for Musculoskeletal Health, The University of Sydney and Sydney Local Health District, Australia. Electronic address:
Objectives: To develop and user-test a patient decision aid providing evidence-based information for people with chronic low back pain (LBP) and degenerative disc disease considering lumbar fusion.
Design: Convergent parallel mixed methods study.
Setting: A prototype patient decision aid was developed, guided by the International Patient Decision Aid Standards (IPDAS) criteria, a multidisciplinary steering committee, and insights from previous studies.
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