AI Article Synopsis
- The report focuses on a case of acute promyelocytic leukemia (APL) M3 with an initial diagnosis characterized by the t(15;17) chromosomal translocation.
- After treatment with chemotherapy and retinoic acid, the patient achieved complete remission, resulting in a normal karyotype.
- Upon relapse, the original t(15;17) was absent, replaced by a t(3;6) translocation, leading to discussions on potential explanations for this unexpected genetic change.
Article Abstract
This report describes a case of acute promyelocytic leukemia (APL) M3. At diagnosis, the specific t(15;17) translocation was observed. After chemotherapy including retinoic acid, a complete remission was achieved and the karyotype became normal. At relapse of the M3 leukemia, the t(15;17) clone was no longer observed but a t(3;6) translocation was then detected. Several hypotheses for this unusual cytogenetic course of APL are discussed.
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| http://dx.doi.org/10.3109/10428199509059675 | DOI Listing |
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