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The Efficacy and Adverse Effects of Sugammadex and Neostigmine in Reversing Neuromuscular Blockade Inpatients with Obesity Undergoing Metabolic and Bariatric Surgery: A Systematic Review with Meta-Analysis and Trial Sequential Analysis.
Medicina (Kaunas)
November 2024
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Article Synopsis
- Metabolic and bariatric surgery (MBS) is used globally, and this study explores the benefits of sugammadex in reversing neuromuscular blockade (NMB) for obese patients undergoing the procedure, comparing it to neostigmine.*
- The systematic review analyzed data from nine studies involving 633 patients, finding that sugammadex led to significantly quicker recovery times and reduced risks of postoperative complications like residual curarization, nausea, vomiting, and cardiovascular issues.*
- The findings suggest that sugammadex is a more effective and safer option than neostigmine for managing NMB in obese patients during bariatric surgeries.*
Semicircular canal drug delivery safely targets the inner ear perilymphatic space.
JCI Insight
November 2024
Department of Otolaryngology, Stanford University School of Medicine, Stanford, California, USA.
Effective, reproducible, and safe delivery of therapeutics into the inner ear is required for the prevention and treatment of hearing loss. A commonly used delivery method is via the posterior semicircular canal (PSCC); however, its specific targeting within the cochlea remains unclear, impacting precision and reproducibility. To assess safety and target specificity, we conducted in vivo recordings of the pharmacological manipulations delivered through the PSCC.
View Article and Find Full Text PDFHow histopathological diagnosis interacts with kidney ultrasound parameters and glomerular filtration rate.
Intern Emerg Med
November 2024
Nephrology, Dialysis and Transplantation Unit, Department of Emergency and Organ Transplantation, University of Bari Aldo Moro, Bari, Italy.
The evaluation of estimated GFR (eGFR) is a pivotal staging step in patients with chronic kidney disease (CKD), and renal ultrasound plays an important role in diagnosis, prognosis and progression of CKD. The interaction between histopathological diagnosis and ultrasound parameters in eGFR determination has not been fully investigated yet. The study examined the results of native kidney biopsies performed in 48 Italian centers between 2012 and 2020.
View Article and Find Full Text PDFDiaphragm ultrasonography as a monitor in assessing antagonistic effect of sugammadex on rocuronium in patients with Child-Pugh grades A and B.
Front Med (Lausanne)
April 2024
Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Background: Although diaphragm ultrasound can be used for detecting residual neuromuscular blockade post-surgery, there exists notable dearth in contemporary research exploring the correlation between preoperative Child-Pugh classification and the effectiveness of sugammadex in reversing rocuronium-induced blockade as evaluated by diaphragmatic ultrasonography.
Methods: This was a prospective, double-blind, non-randomized controlled clinical trial conducted on patients scheduled for laparoscopic liver resection surgery. The participants were categorized into two groups, A and B, based on their preoperative Child-Pugh classification.
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