[The preliminary results of a study of the role of endogenous nitric oxide in pregnant women with chronic glomerulonephritis, hypertension and puerperal eclampsia].

NO-synthase activity and formation of ERP/NO were evaluated in 19 pregnant women by high activity of platelet guanylate-cyclase (GC) and presence of z-arginine. The examinees were divided into 4 groups: 3 women with chronic glomerulonephritis (CGN), 9 patients with essential hypertension (EH), 3 nonpregnant women of reproductive age with EH, 3 healthy pregnant women. One patient had puerperal eclampsia. Z-arginine activation failed to change GC activity in healthy pregnant women, reduced it in pregnant and nonpregnant women with EH, increased GC activity 1.6-fold in a patient with puerperal eclampsia and in CGN pregnant females. It is inferred that changes in NO-dependent synthesis of cGMP manifested more distinctly in a patient with puerperal eclampsia.