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The impact of N-acetylcysteine on hypoxia-induced testicular apoptosis in male rats: TUNEL and IHC findings.
Heliyon
November 2024
Department of Anatomical sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Article Synopsis
- The study investigated the effects of N-acetylcysteine (NAC) on testicular hypoxia caused by varicocele in mature Wistar rats, focusing on gene regulation related to apoptosis and oxidative stress.
- Thirty-two rats were divided into four groups (Control, hypoxia, hypoxia treated with NAC, and healthy animals treated with NAC), with significant improvements in testicular health observed in the NAC-treated group after eight weeks.
- Results showed that NAC increased antioxidant levels and reduced markers of oxidative stress, lowered apoptosis rates in germ cells, and improved histopathological parameters, indicating its potential as a protective treatment for testicular damage from hypoxia.
May-Thurner Syndrome Causing Unilateral Varicocele Treated With Endovascular Embolization.
Cureus
November 2024
Internal Medicine, Dr. Sulaiman Al Habib Medical Group, Buraidah, SAU.
May-Thurner syndrome is a rare disorder characterized by the right common iliac artery overlies and compresses the left common iliac vein against the lumbar spine with or without iliofemoral deep venous thrombosis (DVT). The majority of cases are female and have been associated with the development of vulvar varicosities, particularly during pregnancy. Interestingly and very rarely, this condition has also been identified as a potential cause of varicoceles in males.
View Article and Find Full Text PDFUrological Examination Compared to Ultrasonography in Testicular Lump Assessment: A Retrospective Cohort Study.
Cureus
October 2024
Urology, Royal Bournemouth Hospital, Bournemouth, GBR.
Background General practitioners (GPs) often expedite indeterminate scrotal lumps for urological evaluation. While a scrotal examination by a urologist is crucial, ultrasound (US) has become a routine component of clinical assessment regardless of the clinical examination findings and the nature of the symptoms. This study aimed to evaluate the efficacy of clinical examination compared to scrotal ultrasound, even when the suspicion of cancer was low.
View Article and Find Full Text PDFAn Incidental Finding of Posterior Nutcracker Syndrome: A Case Report.
Cureus
October 2024
Radiology, Osmania Medical College, Hyderabad, IND.
Posterior nutcracker syndrome (PNCS) is a rare vascular disorder involving the compression of the retro-aortic left renal vein between the aorta and the vertebral column. It often presents with left flank pain, hematuria, and varicocele. We report the case of a 39-year-old male who presented with diffuse abdominal pain, acute urinary retention, and left flank pain.
View Article and Find Full Text PDFDecoding Acute Scrotum: Diagnostic Accuracy of Ultrasound in Urgent Clinical Settings.
Cureus
October 2024
Radiodiagnosis, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Puducherry, IND.
Background Acute scrotum is a medical emergency commonly encountered in clinical practice, particularly in pediatric and adolescent populations. It is characterized by sudden onset of scrotal pain and may involve swelling, redness, or tenderness. The most common etiologies include testicular torsion, epididymo-orchitis, trauma, and, less frequently, tumors.
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