AI Article Synopsis
- Radiation synovectomy was conducted on 135 patients, involving a total of 417 joints, with different radionuclides used for treatment based on the joint type.
- After three years, 70-80% of patients showed a positive response, with 50-60% achieving complete treatment effects, which were maintained in 55-60% of cases over eight years.
- The knee joints showed the best therapeutic outcomes, while the wrist joints had the least favorable results, and the total radiation dose for each patient was carefully managed throughout the treatment period.
Article Abstract
Radiation synovectomy (RSIN) with radionuclide combination (N) was performed in 135 patients with rheumatoid arthritis or 417 joints: 155 knee joints (90Y), 230 MCF or PIF joints (169Er), 17 ankle, 7 wrist, 6 elbow and 2 shoulder joints (186Re). Therapeutic effect was followed up during 8 year period. After 3 years positive effect of the treatment was achieved in 70-80% of cases and complete treatment in 50-60% of cases, while 8 years later the same effects were maintained in 55-60%, i.e. 35-40% of the treated joints. The best effect was achieved in the treatment of the knee and the worst in the treatment of the wrist joint. At simultaneous application of one or several different RN, the total dose for one patient did not exceed 259 MBq while the maximum dose was 695 MBq during the long-term treatment.
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