At present less than 30% of the market lambs slaughtered in the United States meet the requirements for leanness and muscling as specified in the "Certified Fresh American Lamb" program established in 1990 by the American Sheep Industry Association (ASI). Carcass composition of slaughter lambs is determined by stage of growth relative to mature size, genotype, sex, and matching dietary nutriment to nutrient requirements for lean tissue growth. On the average, current production strategies produce carcasses that contain excessive amounts of fat, impeding optimized efficiency at all levels of production. Use of large-mature-size terminal sires, feeding rumen-escape dietary protein, feeding intact males, and slaughtering at appropriate weights all improve composition of gain. Improvements of 10 to 20% in rates of gain and efficiency of nutrient use and similar reductions in feed cost can be achieved with each of these management strategies. Results from several experiments demonstrate that these effects are additive and provide a measure of the true genetic capacity for protein accretion rate in growing lambs. Adoption of these management strategies will allow lambs to be slaughtered at a younger age, which may improve meat quality and concurrently reduce the amount of nitrogen waste returned to the environment. Potential for further manipulation of composition exists through more accurately defining nutrient requirements of growing lambs and through use of metabolism modifiers. Maintaining a competitive, profitable, and sustainable sheep industry depends on continued improvement of production efficiency, preferably in systems with high reproductive rates.
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http://dx.doi.org/10.2527/1995.7382493x | DOI Listing |
JMIR Med Inform
January 2025
INSERM U1064, CR2TI - Center for Research in Transplantation and Translational Immunology, Nantes University, 30 Bd Jean Monnet, Nantes, 44093, France, 33 2 40 08 74 10.
Precision medicine involves a paradigm shift toward personalized data-driven clinical decisions. The concept of a medical "digital twin" has recently become popular to designate digital representations of patients as a support for a wide range of data science applications. However, the concept is ambiguous when it comes to practical implementations.
View Article and Find Full Text PDFBMC Pharmacol Toxicol
January 2025
Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Objective: Cyclin-dependent kinase (CDK)-4/6 inhibitors have significantly improved outcomes in several cancers but can also induce various organ system toxicities, including musculoskeletal disorders. This study aimed to comprehensively characterize the musculoskeletal adverse events (MSAEs) associated with CDK4/6 inhibitors based on real-world data.
Methods: Reports of MSAEs linked to CDK4/6 inhibitors from the first quarter (Q1) of 2015 and 2023 Q4 were extracted from the FAERS.
J Transl Med
January 2025
Department and Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jiefang Avenue, Wuhan, Wuhan, 430030, P.R. China.
Introduction: Prostate cancer is one of the most common cancers in the United States with a high mortality rate. In recent years, the traditional opinion about prostate microbiome was challenged. Although there still are some arguments, an escalating number of researchers are shifting their focus toward the microbiome within the prostate tumor environment.
View Article and Find Full Text PDFJ Health Popul Nutr
January 2025
Department of Public Health Sciences, University of Rochester Medical Center, Saunders Research Building Crittenden Blvd, Rochester, New York, 14642, USA.
Background: No study has assessed the impact of flavor capsule cigarettes (FCCs) on smoking cessation. Thus, the purpose of this exploratory study was to assess (1) the sociodemographic and smoking-related characteristics associated with using FCCs, and (2) the preliminary impact of FCCs on smoking cessation.
Methods: This study is a secondary data analysis of a single-arm study with 100 individuals living in Mexico who smoked and received a smoking cessation mHealth intervention and pharmacotherapy support.
Addict Sci Clin Pract
January 2025
Department of Medicine, Division of General Internal Medicine, University of Washington/Harborview Medical Center, 325 9Th Avenue, Box 359780, Seattle, WA, 98104, USA.
Background: Initiation of buprenorphine for treatment of opioid use disorder (OUD) in acute care settings improves access and outcomes, however patients who use methamphetamine are less likely to link to ongoing treatment. We describe the intervention and design from a pilot randomized controlled trial of an intervention to increase linkage to and retention in outpatient buprenorphine services for patients with OUD and methamphetamine use who initiate buprenorphine in the hospital.
Methods: The study is a two-arm pilot randomized controlled trial (N = 40) comparing the mHealth Incentivized Adherence Plus Patient Navigation (MIAPP) intervention to treatment as usual.
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