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Objective: To evaluate the therapeutic effects of Kuanxiong Aerosol (KXA) on ischemic stroke with reperfusion and elucidate the underlying pharmacological mechanisms.

Methods: In vivo pharmacological effects on ischemic stroke with reperfusion was evaluated using the transient middle cerebral artery occlusion (t-MCAO) mice model. To evaluate short-term outcome, 30 mice were randomly divided into vehicle group (n=15) and KXA group (n=15).

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Superhydrophobic surfaces, known for their exceptional water-repellent properties with contact angles exceeding 150°, are highly regarded for their effectiveness in applications including self-cleaning, antifouling, and ice prevention. However, the structural fragility and weak durability of conventional coating limit their long-term use. In this research, a new approach is proposed for the fabrication of long-lasting superhydrophobic surfaces using ethyl cyanoacrylate (ECA) and a primer.

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Lubrication surfaces reduce the risk of cross-contamination and enhance the long-term stability of medical devices, which holds significance in the realm of antifouling medical materials. However, the complexity of constructing micronano structures to immobilize lubricating fluids and the fluorine content typically found in silane coupling agents restrict their widespread adoption. In this study, we prepared a biomimetic lubricating coating (BLC) through the one-step self-assembly of octadecyltrichlorosilane and oil infusion.

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Pterostilbene protects against lipopolysaccharide-induced inflammation and blood-brain barrier disruption in immortalized brain endothelial cell lines in vitro.

Sci Rep

January 2025

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China.

Brain microvascular endothelial cells are connected by tight junction (TJ) proteins and interacted by adhesion molecules, which participate in the selective permeability of the blood-brain barrier (BBB). The disruption of BBB is associated with the progression of cerebral diseases. Pterostilbene is a natural compound found in blueberries and grapes with a wide range of biological activities, including anti-inflammatory, antioxidant, and anti-diabetic effects.

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Bioadhesives and bioactive hydrogels for wound management.

J Control Release

January 2025

Department of Bioengineering and Nano-Bioengineering, College of Life Sciences and Bioengineering, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Republic of Korea; Research Center for Bio Materials & Process Development, Incheon National University, 119 Academy-ro, Yeonsu-gu, Incheon 22012, Republic of Korea. Electronic address:

Delayed wound healing remains a major challenge in biomedical research, often leading to complications such as scarring, acute trauma, and chronic diseases. Effective wound management is crucial for enhancing treatment outcomes, preventing complications, and promoting tissue regeneration. In response to this need, a variety of polymeric biomaterials have been developed.

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