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Clinical research framework proposal for ketogenic metabolic therapy in glioblastoma.
BMC Med
December 2024
Biology Department, Boston College, Chestnut Hill, MA, 02467, USA.
Article Synopsis
- Glioblastoma (GBM) is the deadliest brain tumor in adults, and current therapies are largely ineffective, which drives the need for new treatment strategies based on the tumor's metabolic needs, specifically glucose and glutamine.
- A ketogenic metabolic therapy (KMT) approach targets these metabolic pathways by combining dietary changes with specific drugs to limit glycolysis and glutaminolysis, while promoting the use of non-fermentable fuels like ketones and fatty acids.
- The glucose-ketone index (GKI) serves as a biomarker to monitor treatment effectiveness, aiming to create a more hostile environment for tumor growth and improve outcomes in GBM as well as potentially other cancer types reliant on similar metabolic pathways.
Metabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction.
Circ Heart Fail
November 2024
Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC (S.S., R.W.M., R.J.M., S.H.S.).
Article Synopsis
- The study investigates how SGLT2 inhibitors, particularly dapagliflozin, affect metabolism in patients with heart failure (HF) differing by ejection fraction (EF), focusing on ketone and fatty acid changes.
- It analyzed data from two trials involving 527 participants, using metabolomic profiling to identify the effects of dapagliflozin on various metabolites over 12 weeks.
- The findings revealed that dapagliflozin increased certain metabolites associated with ketosis and acylcarnitines but had less effect on amino acids, showing varying impacts depending on the patient's left ventricular ejection fraction.
A 3-Week Ketogenic Diet Increases Skeletal Muscle Insulin Sensitivity in Individuals With Obesity: A Randomized Controlled Crossover Trial.
Diabetes
October 2024
Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark.
A ketogenic diet (KD) can induce weight loss and improve glycemic regulation, potentially reducing the risk of type 2 diabetes development. To elucidate the underlying mechanisms behind these beneficial effects of a KD, we investigated the impact of a KD on organ-specific insulin sensitivity (IS) in skeletal muscle, liver, and adipose tissue. We hypothesized that a KD would increase IS in skeletal muscle.
View Article and Find Full Text PDFKetogenic Diet and Progression of Kidney Disease in Animal Models of Nephropathic Cystinosis.
J Am Soc Nephrol
November 2024
Laboratory of Nephrology, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
Key Points: Ketogenic diet can change the metabolism in the body and helped restore the function of altered pathways in nephropathic cystinosis. Ketogenic diet had significant benefits for preventing kidney damage, even when initiated after the onset of kidney impairment. Ketogenic diet may provide a partial therapeutic alternative in countries where cysteamine therapy is too expensive.
View Article and Find Full Text PDFBDH1-mediated βOHB metabolism ameliorates diabetic kidney disease by activation of NRF2-mediated antioxidative pathway.
Aging (Albany NY)
November 2023
Department of Endocrinology and Metabolism, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
A ketogenic diet (KD) and β-hydroxybutyrate (βOHB) have been widely reported as effective therapies for metabolic diseases. β-Hydroxybutyrate dehydrogenase 1 (BDH1) is the rate-limiting enzyme in ketone metabolism. In this study, we examined the BDH1-mediated βOHB metabolic pathway in the pathogenesis of diabetic kidney disease (DKD).
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