Objectives: The aim of this study was to determine the influence of the degree of porosity on the release of growth factors (PDGF AA, PDGF BB, bFGF) by healing PTFE grafts.
Design And Setting: Laboratory animal study.
Materials: 1 cm long segments of non-reinforced PTFE grafts (30 microns fibril length, 2 mm internal diameter, 0.39 mm thick) were placed as an abdominal aortic interposition in Lewis rats. Fifteen grafts served as control (Group A; porous grafts); in eight rats (Group B; non porous grafts) the PTFE graft was completely wrapped by a non-porous plastic envelope. Animals were killed 4 weeks after surgery.
Outcome Measures: The release of PDGF AA, PDGF BB and bFGF was assessed by Enzyme Linked Immunosorbent Assay (ELISA).
Results: The release of PDGF AA, PDGF BB and bFGF was statistically higher in porous grafts. The only histological difference between the two groups was that porous PTFE grafts were invaded by many tufts of capillaries from the surrounding tissue, whereas this phenomenon was absent in non porous PTFE grafts.
Conclusions: The degree of porosity influences the release of growth factors by healing PTFE grafts. This fact may have implication in the endothelisation of PTFE grafts and in myointimal hyperplasia formation as well.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s1078-5884(96)80132-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical Outcomes After Tracheobronchoplasty With Ringed Polytetrafluoroethylene Vascular Graft.
Ann Thorac Surg Short Rep
December 2023
Department of Cardiovascular and Thoracic Surgery, Mayo Clinic Florida, Jacksonville, Florida.
Background: This report describes the surgical technique and outcomes of tracheobronchoplasty (TBP) with ringed polytetrafluoroethylene (PTFE) vascular graft.
Methods: We identified all patients who underwent PTFE-TBP for severe expiratory central airway collapse from January 1, 2018 to August 2021 at Mayo Clinic, Florida. Preoperative and postoperative St George's Respiratory Questionnaire (SGRQ), Cough-Specific Quality of Life Questionnaire (CSQLQ), pulmonary function testing, 6-minute walk test, and blinded dynamic bronchoscopy videos at 3-month follow-up were used to assess outcomes.
Long-Term Outcomes With Expanded Polytetrafluoroethylene Valved Conduits in Pediatric Patients.
Ann Thorac Surg Short Rep
December 2024
Institute for Integrated Life Skills, LLC, Bermuda Run, North Carolina.
Background: The expanded polytetrafluoroethylene (ePTFE) valved conduit (VC) has been reported for pulmonary valve replacement (PVR). The purpose of this study was to review long-term outcomes of our trileaflet ePTFE VC.
Methods: This multicenter study was performed with institutional review board approval from each institution.
Modified Blalock-Thomas-Taussig Shunt Using Femoral Artery Homograft.
Ann Thorac Surg Short Rep
March 2023
Department of Congenital Cardiothoracic Surgery, NYU Grossman School of Medicine, NYU Langone Health, New York, New York.
Modified Blalock-Thomas-Taussig shunts are typically performed with biosynthetic polytetrafluoroethylene grafts. However, biologic conduits are being increasingly investigated. We herein report a case in which a femoral artery homograft was effectively used as material for a Blalock-Thomas-Taussig shunt.
View Article and Find Full Text PDFOpen Distal Venous Arterialization Technique as an Opportunity for Patients With Critical Limb Ischemia: A Latin American Experience.
Vasc Endovascular Surg
January 2025
Vascular Surgery Department, Hospital Militar Central, Bogotá, Colombia.
Background: Chronic limb-threatening ischemia (CLTI) leads to decreased quality of life and increased disease burden, resulting in progressive patient deterioration, limb amputation, and mortality.
Objectives: This study aims to present the outcomes of a Latin American experience using the open distal venous arterialization (DVA) technique for no-option limb salvage in a high volume CLTI center.
Methods: A retrospective case series study was performed including patients from 2018 to 2022 using a population from Bogotá, Colombia.
Left Common Iliac Artery Aneurysm Rupture to an Iliac Vein with a Venous Anomaly: A Case Report.
Ann Vasc Dis
December 2024
Department of Cardiovascular Surgery, Nagoya City University East Medical Center, Nagoya, Aichi, Japan.
Ruptured iliac artery aneurysms are serious conditions with high mortality, occasionally perforating into the venous system. A 73-year-old male presented with left leg edema and a pulsatile left lower abdominal mass. Computed tomography revealed a ruptured left common iliac artery aneurysm with perforation into the left common iliac vein.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!