Influence of 6-hydroxydopamine (6-OHDA) on catecholaminergic brain system and development of early behavioural patterns was studied in 1-20-days-old Wistar rats. After 6-OHDA neonatal injection the number on catecholaminergic terminals in deep layers of pons-medulla was considerably reduced while the number of catecholaminergic neurons was 2-3 times increased. Damage of catecholaminergic innervation of the forebrain of rats was shown to cause a delay in development of washing behaviour, searching activity and disturbance of orientation in new environment.
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Introduction: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder among children and adolescents. The disorder negatively influences their academic performance and social relations, and their quality of life (QoL) is lower than that of peers without ADHD. The majority of children and adolescents with ADHD are treated with medication that potentially has an insufficient effect or frequently occurring adverse events.
View Article and Find Full Text PDFDisparate molecular mechanisms in cardiac ryanodine receptor channelopathies.
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Swansea University Medical School, Institute of Life Science, Swansea, United Kingdom.
Aims: Mutations in the cardiac ryanodine receptor (RyR2) are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). This study investigates the underlying molecular mechanisms for CPVT mutations within the RyR2 N-terminus domain (NTD).
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Copy Number Variants in Cardiac Channelopathies: Still a Missed Part in Routine Arrhythmic Diagnostics.
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November 2024
Cardiogenetic Center, Rare Diseases and Medical Genetics Units, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
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View Article and Find Full Text PDFSudden Cardiac Death and Channelopathies: What Lies behind the Clinical Significance of Rare Splice-Site Alterations in the Genes Involved?
Genes (Basel)
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Section of Legal Medicine, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Via Tronto, 60126 Ancona, Italy.
Article Synopsis
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Fos expression in A1/C1 neurons of rats exposed to hypoxia, hypercapnia, or hypercapnic hypoxia.
Neurosci Lett
November 2024
Laboratory of Veterinary Anatomy and Cell Biology, Faculty of Agriculture, Iwate University, 18-8, Ueda 3-chome, Morioka, Iwate 020-8550, Japan. Electronic address:
The distribution of Fos expression in catecholaminergic neurons with immunoreactivity for dopamine β-hydroxylase (DBH) of the ventrolateral medulla was compared between rats exposed to hypoxia (10 % O), hypercapnia (8 % CO), and hypercapnic hypoxia (8 % CO and 10 % O) for 2 h. Among the experimental groups, hypoxia-exposed rats had more Fos/DBH double-immunoreactive neurons than the control group (20 % O) in the rostral area of the ventrolateral medulla, specifically in the range of + 150 μm to + 2,400 μm from the caudal end of the facial nerve nucleus. On the other hand, Fos/DBH double-immunoreactive neurons were scarcely observed in the ventrolateral medullary region of hypercapnia-exposed rats.
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