The transcription-translation process in the virus-host cell system is analyzed in terms of a virtual neural network. In contrast to findings in the transcription-translation process in eukaryotic cells, an inverse correlation between the frequency of protein amino acids and code degeneracy and between code degeneracy and the rate of amino acid substitutions was not found. Misuse of the virtual host cell network by virus protein synthesis could be attributed to the different amino acid composition of the virus proteins (input unit) studied here.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF01701810 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deciphering the Coupling State-Dependent Transcription Termination in the Escherichia coli Galactose Operon.
Mol Microbiol
January 2025
Department of Biological Sciences, College of Biological Sciences and Biotechnology, Chungnam National University, Daejeon, Republic of Korea.
The distance between the ribosome and the RNA polymerase active centers, known as the mRNA loop length, is crucial for transcription-translation coupling. Despite the existence of multiple expressomes with varying mRNA loop lengths, their in vivo roles remain largely unexplored. This study examines the mechanisms governing transcription termination in the Escherichia coli galactose operon, revealing a crucial role in the transcription and translation coupling state.
View Article and Find Full Text PDFRibosome biogenesis is pivotal in the self-replication of life. In Escherichia coli, three ribosomal RNAs and 54 ribosomal proteins are synthesized and subjected to cooperative hierarchical assembly facilitated by numerous accessory factors. Realizing ribosome biogenesis in vitro is a critical milestone for understanding the self-replication of life and creating artificial cells.
View Article and Find Full Text PDFThe future of cell-free synthetic biology.
Biotechnol Notes
November 2024
Department of Chemical Engineering, Tsinghua University, Beijing 100084, China.
Cell-free synthetic biology aims at the targeted replication, design, and modification of life processes in open systems by breaking free of constraints such as cell membrane barriers and living cell growth. The beginnings of this systematized technology, which took place in the last century, were used to explore the secrets of life. Currently, with its easy integration with other technologies or disciplines, cell-free synthetic biology is developing into a powerful and effective means of understanding, exploiting, and extending the structure and function of natural living systems.
View Article and Find Full Text PDFComplex gene-dependent and-independent mechanisms control daily rhythms of hematopoietic cells.
Biomed Pharmacother
January 2025
Department of Experimental Medicine, Sapienza University of Rome, Rome 00161, Italy. Electronic address:
The abundance and behaviour of all hematopoietic components display daily oscillations, supporting the involvement of circadian clock mechanisms. The daily variations of immune cell functions, such as trafficking between blood and tissues, differentiation, proliferation, and effector capabilities are regulated by complex intrinsic (cell-based) and extrinsic (neuro-hormonal, organism-based) mechanisms. While the role of the transcriptional/translational molecular machinery, driven by a set of well-conserved genes (Clock genes), in nucleated immune cells is increasingly recognized and understood, the presence of non-transcriptional mechanisms remains almost entirely unexplored.
View Article and Find Full Text PDFStress sensing and response through biomolecular condensates in plants.
Plant Commun
December 2024
Center for Plant Biology, School of Life Sciences, Tsinghua University; Beijing, 100084, China. Electronic address:
In response to environmental stressors, plants have developed intricate mechanisms for rapid and efficient stress perception and adaptation. Recent research highlights the emerging role of biomolecular condensates in modulating plant stress sensing and response. These condensates function via numerous mechanisms to regulate cellular processes such as transcription, translation, RNA metabolism, and signaling pathways under stress conditions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!