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Optimizing lipopeptide bioactivity: The impact of non-ionic surfactant dressing.
J Pharm Anal
December 2024
MTA-HUN-REN TTK Lendület "Momentum" Peptide-Based Vaccines Research Group, Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Budapest, H-1117, Hungary.
The aim of the research is to increase the applicability of lipopeptides as drugs. To this end, non-ionic triblock copolymers, namely poloxamers, were applied. The physico-chemical properties of poloxamers vary depending on the length of the blocks.
View Article and Find Full Text PDFUtilization of AF4 for characterizing complex nanomaterial drug products: Reexamining sample recovery and its impact on particle size distribution as a quality attribute.
J Chromatogr A
January 2025
Office of Pharmaceutical Quality Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland 20993, USA. Electronic address:
Asymmetrical flow field-flow fractionation (AF4) with multi-detection has continued to gain wider acceptance for characterizing complex drug products. An important quality attribute for these products is the measurement of the particle size distribution (PSD). Current limitations of established procedures (e.
View Article and Find Full Text PDFReversible Redox Controlled DNA Condensation by a Simple Noncanonical Dicationic Diphenylalanine Derivative.
Biopolymers
March 2025
Departmento de Química Inorgánica y Orgánica, Universidad Jaume I, Castellón, Spain.
We report the reversible redox-controlled DNA condensation using a simple dicationic diphenylalanine derivative which contains a disulfide unit as linker. Despite the conventional belief that DNA condensing agents require a charge of +3 or higher, this dicationic molecule functions below its critical aggregation concentration, representing a non-canonical DNA condensing agent. The interaction with DNA of the studied compound combines electrostatic effects with hydrophobic/stacking interactions provided with the diphenylalanine moiety.
View Article and Find Full Text PDFManufacturing of Liposomes Using a Stainless-Steel Microfluidic Device: An Investigation into Design of Experiments.
Langmuir
January 2025
Department of Polymer and Materials Chemistry, Faculty of Chemistry & Petroleum Sciences, Shahid Beheshti University, P.O. Box 1983969411 Tehran, Iran.
Liposomes are highly beneficial nanocarrier systems due to their biocompatibility, low toxicity, and exceptional inclusiveness, which lead to improved drug bioavailability. For biological applications, accurate control over these nanoparticles' mean size and size distribution is essential. Micromixers facilitate the continuous production of liposomes, enhancing the precision of size regulation and reproducibility.
View Article and Find Full Text PDFChitosan-DNA nanoparticles: synthesis and optimization for long-term storage and effective delivery.
PeerJ
January 2025
Department of Biology, School of Sciences and Humanities, Nazarbayev University, Astana, Kazakhstan.
Background: Chitosan nanoparticles (CsNPs) are an effective and inexpensive approach for DNA delivery into live cells. However, most CsNP synthesis protocols are not optimized to allow long-term storage of CsNPs without loss of function. Here, we describe a protocol for CsNP synthesis, lyophilization, and sonication, to store CsNPs and maintain transfection efficiency.
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