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Trends in tuberculosis mortality among older adults in China, 2004-2021: a Joinpoint regression and age-period-cohort analysis.
Front Public Health
January 2025
Office of Education and Training (Graduate School), Chinese Center for Disease Control and Prevention, Beijing, China.
Background: Tuberculosis (TB) remains a major public health problem in China and globally, particularly among older adults. This study aimed to examine secular trends in TB mortality among older adults in China and the net effects of age, period, and cohort.
Methods: Data from the National Disease Surveillance Points (DSPs) system were analyzed using Joinpoint regression to determine annual changes in TB mortality among individuals aged 60 years and older from 2004 to 2021.
AntiBinder: utilizing bidirectional attention and hybrid encoding for precise antibody-antigen interaction prediction.
Brief Bioinform
November 2024
Research Center for Social Intelligence, Fudan University, Handan Street, Shanghai 200433, China.
Antibodies play a key role in medical diagnostics and therapeutics. Accurately predicting antibody-antigen binding is essential for developing effective treatments. Traditional protein-protein interaction prediction methods often fall short because they do not account for the unique structural and dynamic properties of antibodies and antigens.
View Article and Find Full Text PDFCrucial role of the cGAS N terminus in mediating flowable and functional cGAS-DNA condensate formation via DNA interactions.
Proc Natl Acad Sci U S A
January 2025
Department of General Surgery, The First Affiliated Hospital of University of Science and Technology of China, Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science Interdisciplinary Science & Biomedicine of Institute of Health and Medicine, Division of Life Sciences & Medicine, University of Science and Technology of China, Hefei 230027, Anhui, China.
The DNA-sensing protein cGAS plays a pivotal role in the innate immune response and pathogenesis of various diseases. DNA triggers liquid-liquid phase separation (LLPS) and enhances the enzymatic activity of cGAS. However, the regulatory mechanisms of the disordered N terminus remain unclear.
View Article and Find Full Text PDFIntegrative genomics would strengthen AMR understanding through ONE health approach.
Heliyon
July 2024
Division of Immunology and Infectious Disease Biology, INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) Laboratory, CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Mall Road, Delhi, 110007, India.
Emergence of drug-induced antimicrobial resistance (AMR) forms a crippling health and economic crisis worldwide, causing high mortality from otherwise treatable diseases and infections. Next Generation Sequencing (NGS) has significantly augmented detection of culture independent microbes, potential AMR in pathogens and elucidation of mechanisms underlying it. Here, we review recent findings of AMR evolution in pathogens aided by integrated genomic investigation strategies inclusive of bacteria, virus, fungi and AMR alleles.
View Article and Find Full Text PDFDAMPs, PAMPs, NLRs, RIGs, CLRs and TLRs - Understanding the Alphabet Soup in the Context of Bone Biology.
Curr Osteoporos Rep
January 2025
Department of Immunology, Tufts University, Boston, MA, 02111, USA.
Purpose Of Review: The purpose of this review is to summarize the current understanding of cell-autonomous innate immune pathways that contribute to bone homeostasis and disease.
Recent Findings: Germ-line encoded pattern recognition receptors (PRRs) are the first line of defense against danger and infections. In the bone microenvironment, PRRs and downstream signaling pathways, that mount immune defense, interface intimately with the core cellular processes in bone cells to alter bone formation and resorption.
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