A retrospective study of acute stroke diagnosed in the last ten years (20 cases: 12 girls and 8 boys) with an incidence rate of 1.26 cases per year per 100,000 inhabitants under 15 years of age) in our health area. Average age; 7.83 years (range: 2 months to 15 years). Confirming diagnosis was performed by computerised tomography (CT) scan, magnetic resonance (MR) imaging, echography and/or cerebral arteriography. Ten cases of ischaemic stroke and ten of haemorrhagic stroke were catalogued. Average follow-up was 5.45 years (range: 9 months to 10.8 years). Fibromuscular dysplasia, arthritis and meningitis are predominant in ischaemic stroke etiology, there also being one case of Moya-Moya. Haemorrhagic strokes are mostly produced by arteriovenous malformation. The predominant presenting form of ischaemic stroke was hemiplegia and of haemorrhagic strokes it was intracranial hypertension. There were no deaths as a result of ischaemic accidents but three in the cerebral haemorrhage group. Treatment was surgical in two cases, embolisation in two others and medical support in the remaining sixteen. There were no cases of relapse, except in the Moya-Moya case. Clinical position and the ability to carry on day to day life were most affected in the cerebral attack cases, which would indicate ischaemic stroke recuperation is worse than that for haemorrhagic strokes.
Download full-text PDF |
Source |
---|
Stem Cell Rev Rep
January 2025
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, India.
Background: Conventional post-stroke edema management strategies are limitedly successful as in multiple cases of hemorrhagic transformation is being reported. Clinically, acute-ischemic-stroke (AIS) intervention by endovascular mesenchymal stem cells (MSCs) have shown benefits by altering various signaling pathways. Our previous studies have reported that intra-arterial administration of 1*10 MSCs (IA-MSCs) were beneficial in alleviating post-stroke edema by modulating PKCδ/MMP9/AQP4 axis and helpful in preserving the integrity of blood-brain-barrier (BBB).
View Article and Find Full Text PDFACS Chem Neurosci
January 2025
CAS Key Laboratory of Animal Models and Human Disease Mechanisms, KIZ-SU Joint Laboratory of Animal Model and Drug Development, Laboratory of Learning and Memory, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China.
Acute ischemic stroke (AIS) is a significant brain disease with a high mortality and disability rate. Additional therapies for AIS are urgently needed, and neuroplasticity mechanisms by agents are expected to be neuroprotective for AIS. As a major active component of Salvia miltiorrhiza, salvianolic acid A (SAA) has shown potential for preventing cardiovascular diseases.
View Article and Find Full Text PDFAlzheimers Dement
January 2025
Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, PR China.
Introduction: Alzheimer's disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia. Recent research highlights meningeal lymphatics as key regulators in neurological diseases, suggesting that enhancing their drainage function could be a potential therapeutic strategy for AD. Our proof-of-concept study demonstrated that cranial bone transport can improve meningeal lymphatic drainage function and promote ischemic stroke recovery.
View Article and Find Full Text PDFAdv Mater
January 2025
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, 200040, P. R. China.
Mesenchymal stem cells (MSCs) transplantation is a promising therapeutic strategy for ischemic stroke. However, the survival of transplanted MSCs is often compromised by the excessive levels of reactive oxygen species (ROS) and calcium ions (Ca) in the ischemic microenvironment following blood flow occlusion. In this study, a protective strategy is developed using functional nanomaterials to escort and shield MSCs.
View Article and Find Full Text PDFCurr Neurovasc Res
January 2025
Department of Epidemiology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-communicable Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College of Soochow University, Suzhou, Jiangsu Province, China.
Background: Plasma osteoprotegerin (OPG) has been linked to poor prognosis following stroke, but its impact on post-stroke cognitive impairment (PSCI) is unknown. The purpose of our work was to analyze the relationship of OPG with PSCI.
Methods: Our study included 613 ischemic stroke subjects with plasma OPG levels.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!