The review deals with biological and medical aspects of oxythiamine biochemistry with special reference to the facts which contradict the traditional antivitamin conception. Alternatives to the coenzyme mechanism in interpreting the metabolic effects of this vitamin B1 derivative are discussed.
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STING exerts antiviral innate immune response by activating pentose phosphate pathway.
Cell Commun Signal
December 2024
School of Life Sciences, Henan University, Kaifeng, Henan Province, China.
Background: The innate immune system serves as the host's first line of defense against invading pathogens. Stimulator of interferon genes (STING) is a key component of this system, yet its relationship with glucose metabolism, particularly in antiviral immunity, remains underexplored.
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View Article and Find Full Text PDFExtraordinary therapeutic effect of PSMA radioligand therapy in treatment-refractory progressive metastatic prostate cancer with the transketolase inhibitor benfo-oxythiamine as a radiosensitizer-A case report.
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View Article and Find Full Text PDFHMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway.
Cell Death Dis
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School of Life Sciences, Henan University, Kaifeng, Henan Province, China.
Esophageal squamous cell carcinoma (ESCC) possesses a poor prognosis and treatment outcome. Dysregulated metabolism contributes to unrestricted growth of multiple cancers. However, abnormal metabolism, such as highly activated pentose phosphate pathway (PPP) in the progression of ESCC remains largely unknown.
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