AI Article Synopsis
- A study analyzed 248 patients with advanced squamous cell carcinoma of the pyriform sinus from 1980 to 1985, focusing on those who underwent total pharyngolaryngectomy followed by radiotherapy.
- The study found a 27.4% local regional recurrence rate, with factors like clinical staging and residual tumor affecting failure rates.
- Overall, the 5-year survival rate was 33%, with a median survival of 32 months, highlighting the poor prognosis despite aggressive treatment approaches.
Article Abstract
Between January 1980 to December 1985, 248 patients with advanced squamous cell carcinoma of the pyriform sinus were retrospectively analysed. Criteria for inclusion in the study were the following: no previous treatment and treatment combining total pharyngolaryngectomy and postoperative radiotherapy. Mean follow up was 5 years with a minimum of 3 years. Seventy-one patients had a local regional recurrence (27.4%). Clinical staging at presentation and residual tumor at the primary site after surgery were factors significantly associated with higher local failure rates. The 5 year survival rate was 33% and the median survival time was 32 months (plateau was reached after the 6th year). The most frequent severe complication observed was pharyngeal stenosis occurring in 6% of the cases. This study confirms the poor prognosis of squamous cell carcinoma of the pyriform sinus, in spite of the combination of radical surgery and high dose postoperative radiotherapy.
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