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Intraoperative Neurophysiologic Monitoring Improves Neurologic Outcomes in Eloquent Brain Areas and Aids in Increasing the Volume of Resected Glioma: Current Results Compared With Historical Controls.
J Clin Neurophysiol
October 2024
Department of Neurological Surgery, Faculty of Medicine, Demiroglu Bilim University, Istanbul, Turkiye.
Purpose: This study aims to show the impact of multimodal intraoperative neurophysiologic monitoring (IOM) in glioma surgery in preventing severe neurologic injury and increasing tumor removal by comparing the historical cases where IOM was not used.
Methods: Fifty-nine patients with glial tumors located nearby the eloquent area, operated by the same surgeon, were included in the study. Between 2008 and 2012, 21 patients were operated on without IOM (non-IOM); between 2018 and 2021, 38 patients were operated on with IOM.
Biomarkers.
Alzheimers Dement
December 2024
Douglas Mental Health Research Centre, Montreal, QC, Canada.
Background: Recent studies suggest that tau pathology spreads between functionally connected (FC) brain regions. The accumulation of amyloid-beta (Aβ) promotes neural hyper-activity in asymptomatic older adults, which might enhance tau spreading. We assessed the relationship between band-specific neurophysiological FC and the rate of tau accumulation over time and tested whether this association is dependent on the presence of Aβ pathology.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Department of Psychiatry, Umass Chan Medical School, Shrewsbury, MA, USA.
Background: The ε4 allele of the apolipoprotein E (APOE4+) genotype and aging synergistically contribute to the risk of Alzheimer's disease (AD), but the mechanisms underlying their influence are not completely understood. The methylation of ELOVL2 DNA accounts for 70% of the variance in the aging epigenetic clock. The ELOVL2 gene is essential for synthesizing long polyunsaturated fatty acids, crucial for cell membrane integrity, inflammation modulation, and energy maintenance.
View Article and Find Full Text PDFBackground: Postoperative delirium (POD) is characterized by fluctuating attention after surgery and is associated with increased risk of developing Alzheimer's Disease (AD). While the neurophysiological changes that underlie POD and increased risk of AD are unclear, recent data has raised the possibility that an exaggerated brain response to anesthetics may be a biomarker for POD risk and preclinical AD-like pathology. Thus, we examined whether anesthetic-dose-adjusted intraoperative brain activity is associated with POD or preoperative brain vulnerabilities (preclinical AD-like pathology, preoperative inattention) that may contribute to risk of POD (and later AD).
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Douglas Mental Health Research Centre, Montreal, QC, Canada.
Background: Recent studies suggest that tau pathology spreads between functionally connected (FC) brain regions. The accumulation of amyloid-beta (Aß) promotes neural hyper-activity in asymptomatic older adults, which might enhance tau spreading. We assessed the relationship between band-specific neurophysiological FC and the rate of tau accumulation over time and tested whether this association is dependent on the presence of Aß pathology.
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