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The Role of [F]F-FDG PET/CT for Predicting Histology and Prognosis in Patients with Thymic Lesions.
Mol Diagn Ther
January 2025
Thoracic Surgery and Lung Transplantation, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122, Milan, Italy.
Objectives: To investigate whether 18F-fluorodeoxyglucose positron emission tomography-computed tomography ([F]F-FDG PET/CT) metabolic parameters were associated with histology and to assess their prognostic role in patients with thymic lesions.
Patients And Methods: In total, 116 patients (49/67 M/F; mean age 59.5 years) who underwent preoperative [F]F-FDG PET/CT and thymectomy from 2012 to 2022 were retrospectively analyzed.
[Thymic Carcinoma Operated After Lung Cancer Operation:Report of a Case].
Kyobu Geka
October 2024
Department of Thoracic Surgery, Okazaki City Hospital, Okazaki, Japan.
A 70-year-old man presented with the growth of an anterior mediastinal nodule on a follow-up computed tomography (CT) scan after undergoing lung cancer surgery. Positron emission tomography (PET)-CT performed at the time of lung cancer surgery did not recognize any accumulation, but PET-CT performed this time confirmed the accumulation of standardized uptake value( SUV) max 5.57.
View Article and Find Full Text PDFUnderstanding how the structures of surfactants in hybrid nanoparticles affect the compaction of ct-DNA for cellular uptake: presenting a highly efficient surfactant.
Soft Matter
December 2024
Department of Chemistry, Birla Institute of Technology & Science (BITS) Pilani, Hyderabad Campus, Hyderabad, Telangana 500078, India.
Article Synopsis
- The study compares the DNA compaction efficiency of two single-head-double-tailed surfactants (DDAB16 and DDAB18) and one triple-head-double-tailed surfactant (MQAS12), finding DDAB18 to be the most efficient and MQAS12 the least.
- Hybrid materials combining surfactants with silica nanoparticles show improved compaction efficiency due to cooperative binding, allowing for effective DNA compaction at lower surfactant concentrations, which reduces cytotoxicity.
- The research indicates that the hydrophobicity and structural characteristics of surfactants and nanoparticles significantly influence DNA compaction, supporting the potential design of safe and efficient non-viral vectors for biomedical applications.
Serial positron-emission tomography after induction therapy as a predictor of prognostic outcomes for patients with thymic carcinoma.
Surg Today
December 2024
Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, 2-15 Yamada-Oka, Suita, Osaka, 565-0871, Japan.
Purpose: To investigate the role of F-fluorodeoxy glucose-positron emission tomography/computed tomography (FDG-PET/CT) to assess pathological response and prognosis after induction therapy in patients with thymic carcinoma.
Methods: The subjects of this retrospective study were 18 patients with thymic carcinoma who underwent FDG-PET, before and after induction therapy. We measured the maximum standardized uptake value (SUVmax) of the tumor and analyzed the correlation between the change in SUVmax and pathological response or recurrence.
Primary thymic mucosa-associated lymphoid tissue (MALT) lymphoma with Sjogren's syndrome and diffuse cystic lung disease: a complex respiratory presentation of a multifaceted autoimmune disease.
BMJ Case Rep
December 2024
University of New South Wales Faculty of Medicine, Sydney, New South Wales, Australia
Article Synopsis
- - Mucosa-associated lymphoid tissue (MALT) lymphoma is a rare B-cell lymphoma that can affect various organs, and patients with Sjögren's syndrome (SjS) have significantly higher risks of developing it.
- - A case study is presented of primary thymic MALT lymphoma found incidentally during routine chest imaging, alongside cystic lung disease, primarily observed in women with SjS.
- - Imaging techniques revealed a large mass in the mediastinum and numerous pulmonary cysts; the diagnosis was confirmed via biopsy, and treatment improved lung function, emphasizing the link between SjS and MALT lymphoma's lung manifestations.
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