AI Article Synopsis
- Cytogenetic studies were conducted on 7 patients with Sezary's syndrome to analyze their chromosomal abnormalities.
- Chromosomal analysis revealed numerical changes in chromosomes 10 and 13, and structural damage in chromosomes 1, 2, 4, 6, and 14.
- While previous findings linked large-cell variants to tetraploidy and small-cell variants to diploidy, this study did not support those associations.
Article Abstract
The cytogenetic studies performed on 7 patients diagnosed of Sezary's syndrome are reported. The chromosomal study was made after 72 hours of culture of phytohaemagglutinin-stimulated peripheral blood. The 7 patients had abnormal karyotypes, the numeral alterations involving chromosomes 10 and 13, whereas the structural abnormalities affected chromosomes 1, 2, 4, 6 and 14. The large-cell variant has been associated with tetraploidy and the small-cell variant with diploidy, but this fact was not confirmed in the present series.
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