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Radiate & Educate: Empowering Future Physicians through an International Radiation Oncology Student Newsletter.
Appl Radiat Oncol
July 2024
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center.
Background: The field of radiation oncology (RO) is frequently overlooked by medical students due to limited exposure during traditional medical school curricula. Initiatives aimed at increasing exposure while creating opportunities for medical student engagement are vital. Here, we present the inception, 1.
View Article and Find Full Text PDFLIN28B-mediated PI3K/AKT pathway activation promotes metastasis in colorectal cancer models.
J Clin Invest
January 2025
Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, United States of America.
Colorectal cancer (CRC) remains a leading cause of cancer death due to metastatic spread. LIN28B is overexpressed in 30% of CRCs and promotes metastasis, yet its mechanisms remain unclear. In this study, we genetically modified CRC cell lines to overexpress LIN28B, resulting in enhanced PI3K/AKT pathway activation and liver metastasis in mice.
View Article and Find Full Text PDFLeptomeningeal Disease in Lung Cancer: An Unmet Need That Needs to Be Met.
J Thorac Oncol
January 2025
Department of Clinical Oncology, Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Developing a Strategy to Increase Lung Cancer Screening in Areas of Need.
Popul Health Manag
December 2024
Division of Population Science, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Lung cancer screening (LCS) rates are low, and lung cancer mortality is high in the United States. This report describes a strategy that health systems can use to identify LCS areas of need and engage associated primary care providers and patients in screening. A research team from Jefferson Health (JH), a large, urban health system, used geocoded standardized lung cancer mortality rates (SMRs) to identify zip codes in Philadelphia where lung cancer mortality is high.
View Article and Find Full Text PDFRacial differences in real-world outcomes of first-line therapies for advanced renal cell carcinoma.
Oncologist
December 2024
Global Health Economics and Outcomes Research, Bristol Myers Squibb, Princeton, NJ 08648, United States.
Background: Given the historical underrepresentation of racial minorities in clinical trials, little is known about racial differences in outcomes of first-line therapies for advanced renal cell carcinoma (aRCC). This study described patient characteristics and clinical outcomes of first-line therapies for aRCC, including nivolumab + ipilimumab, pembrolizumab + axitinib, and tyrosine kinase inhibitors, by race in the real-world setting.
Methods: We conducted a retrospective medical chart review of patients with intermediate/poor-risk clear-cell aRCC.
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