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Comparison of Illumina and Oxford Nanopore sequencing data quality for Clostridioides difficile genome analysis and their application for epidemiological surveillance.
BMC Genomics
January 2025
Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.
Background: The burden of Clostridioides difficile as a nosocomial- and community-acquired pathogen has been increasing over the recent decades, including reports of severe outbreaks. Molecular and virulence genotyping are central for the epidemiological surveillance of this pathogen, but need to balance accuracy and rapid turnaround time of the results. While Illumina short-read sequencing has been adopted as the gold standard to investigate C.
View Article and Find Full Text PDFGenerative AI in a new era of computer model-informed tobacco research: a short report.
Tob Control
January 2025
Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.
Background: Social media influencers who promote e-cigarettes on Instagram or TikTok for tobacco brands use marketing tactics to increase the appeal of their promotional content, for example, depicting e-cigarettes alongside healthy lifestyle or entertainment imagery that could decrease youths' risk perceptions of e-cigarettes. Monitoring the prevalence of such content on social media using computer vision and generative AI (artificial intelligence) can provide valuable data for tobacco regulatory science (TRS).
Methods: We selected 102 Instagram and TikTok videos posted by micro-influencers in 2021-2024 who promoted e-cigarettes alongside posts featuring four themes: cannabis, entertainment, fashion or healthy lifestyle.
Sacubitril/valsartan is associated with improvements in quality of life in adult congenital heart disease patients with systemic right ventricular failure.
Open Heart
January 2025
Center for Congenital Heart Disease Amsterdam Leiden (CAHAL), Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands
Background: Short-term improvements in quality of life (QOL) have been reported in adult congenital heart disease patients with systemic right ventricle (sRV) failure after treatment with sacubitril/valsartan. This study aimed to evaluate the medium-term QOL changes in sRV failure patients treated with sacubitril/valsartan.
Methods: In this single-centre, prospective cohort study, patients with symptomatic sRV failure completed the Netherlands Organisation for Applied Scientific Research/Academic Hospital Leiden Questionnaire for Adult's Health-Related Quality of Life (TAAQOL) at baseline and after starting treatment with sacubitril/valsartan.
Anti-hypercholesterolemic effects of small-molecule pectin from Premna ligustroides Hemsl leaves: Modulation of inflammatory markers and gut microbiota in mice.
Int J Biol Macromol
January 2025
Chongqing Key Laboratory of High Active Traditional Chinese Drug Delivery System, Chongqing Engineering Research Center of Pharmaceutical Sciences, Chongqing Medical and Pharmaceutical College, Chongqing 401331, PR China. Electronic address:
Small-molecule pectin (SMP) extracted from the leaves of Premna ligustroides Hemsl, with a molecular weight range of 5000-35,000 Da, has demonstrated anti-inflammatory and lipid-lowering properties in vitro. This study explored the effects of SMP on hypercholesterolemia in mice, with a focus on inflammation, lipid profiles, and cholesterol metabolism. Mice received SMP at doses of 607, 303, and 152 mg/kg body weight.
View Article and Find Full Text PDFOn-demand celastrol delivery by hyaluronic acid-porphyrinic metal-organic frameworks for synergistic sonodynamic/pharmacological antibacterial therapy.
Int J Biol Macromol
January 2025
Institute of urban Agriculture, Chinese Academy of Agricultural Sciences, Chengdu National Agricultural Science &Technology Center, Chengdu 610213, China; School of Food and Biological Engineering, Chengdu University, Chengdu 610106, China. Electronic address:
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most prevalent bacterial pathogens. The multi-drug resistance and strong biofilm-forming ability make the treatment of MRSA infections challenging. It is urgent to develop antibiotic-free, noninvasive and effective strategies against MRSA infections.
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