Ocular side effects of systemic fluorouracil include excessive lacrimation, due to punctal and canalicular stenosis and fibrosis. Obstruction of the tear ducts after systemic therapy with fluorouracil is more frequent than is assumed. Five patients with breast cancer and punctal or canalicular stenosis are presented. Although complaints of epiphora usually resolve two weeks after cessation of systemic therapy, local antibiotics and steroids may be indicated. In patients with persisting complaints, and patients treated with fluorouracil for a prolonged period of time, prophylactic intubation of the tear ducts with silastic tubes has been advocated. (Conjunctivo)dacryocystorhinostomy may be unavoidable.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/BF01203288 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Morphological analysis of lacrimal punctum using anterior segment optical coherence tomography in different age groups.
Indian J Ophthalmol
February 2025
Department of Orbit and Oculoplasty, Sankara Eye Hospital, Coimbatore, Tamil Nadu, India.
Purpose: To evaluate the lacrimal punctal changes in different age groups using anterior segment optical coherence tomography (AS-OCT).
Methods: A cross-sectional observational study was conducted between January 2023 and January 2024 including healthy subjects between 20 and 80 years. The selected eyes from healthy patients were divided into four age groups (21-35 years, 36-50 years, 51-65 years, 66-80 years), and lower lacrimal puncta were analyzed using AS-OCT.
Evaluation of the Microbiology of Removed Punctal Plugs and Intracanalicular Devices.
Eye Contact Lens
November 2024
Department of Ophthalmology (J.J.M., N.E., W.C.F., A.M.F.), University of North Carolina, Chapel Hill, NC; Department of Ophthalmology (J.J.M.), University of Auckland, Auckland, New Zealand; Tricore Reference Laboratories (K.C.), Albuquerque, NM; Brooke Army Medical Center (E.A.), San Antonio, TX; Medical College of Wisconsin Department of Ophthalmology (N.E.), Milwaukee, WI; Campbell University School of Medicine (W.C.F.), Lillington, NC; Department of Pathology-Laboratory Medicine (P.G.), University of North Carolina School of Medicine, Chapel Hill, NC; and Department of Ophthalmology (A.M.F.), Duke University, Durham, NC.
Article Synopsis
- The study aimed to analyze the types of microorganisms that colonize punctal plugs and intracanalicular stents used for tear insufficiency and eye surgeries.
- The researchers collected and cultured 181 devices from participants and found that over half (54%) were culture positive, revealing a variety of microorganisms, mainly skin and upper respiratory flora.
- No clinical infections were reported, but the findings suggest that these ocular devices can harbor potentially harmful bacteria, indicating a need for monitoring.
Bicanalicular stent versus mono-canalicular stent for post-oncological lacrimal duct reconstruction: A retrospective cohort study.
J Plast Reconstr Aesthet Surg
November 2024
The Lacrimal Center, The Senior Department of Ophthalmology, The Third Medical Center of Chinese PLA General Hospital, 69 Yongding Road, Haidian District, Beijing 100039, China.
Article Synopsis
- This study compares the outcomes of two different types of stents (bicanalicular and mono-canalicular) used for lacrimal duct reconstruction after cancer treatment, as previous comparisons were lacking.
- A total of 75 patients were enrolled and divided into two groups, with significant differences found in stent duration and some postoperative complications like stent prolapse and punctal issues.
- Overall, both stent types were equally effective in maintaining lacrimal duct function and minimizing tear overproduction post-surgery, highlighting the importance of appropriate case selection for optimal results.
Comparison of preoperative and postoperative results of "canalicular triangular flap" and "triangular three-snip" punctoplasty techniques in patients with punctum stenosis using anterior segment optical coherence tomography.
Indian J Ophthalmol
November 2024
Ophthalmology Department, Acibadem Hospital Group, Istanbul, Turkey.
Article Synopsis
- The study aimed to compare two surgical techniques for treating epiphora caused by punctal stenosis: canalicular triangular flap punctoplasty and triangular three-snip punctoplasty, using AS-OCT for assessment.
- A total of 80 eyes from 43 patients were analyzed, with Group A (canalicular triangular flap) achieving a 100% anatomical success and 95% functional success, while Group B (triangular three-snip) achieved 75% anatomical and 77.5% functional success at 6 months.
- The canalicular triangular flap technique was found to be more effective for both anatomical and functional outcomes compared to the three-snip method, highlighting the utility of AS-OCT for diagnosing and tracking punct
Canalicular Cyst After Punctal Plug Insertion.
J Craniofac Surg
October 2024
Department of Ophthalmology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine.
Article Synopsis
- - A 73-year-old male developed a canalicular cyst on his right lower eyelid after having absorbable punctal plugs inserted for dry eye syndrome 8 years earlier.
- - The cyst was found on the medial side of the eyelid, causing ectropion but showing no signs of inflammation; surgical incision and drainage reduced its size.
- - Imaging studies indicated cystic dilation and obstruction in the canaliculus, highlighting that canalicular cysts should be considered when similar patients present with masses in the eye area.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!