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Mechanisms of complex regional pain syndrome.
Front Pain Res (Lausanne)
May 2024
Department of Pain Management and Neurosciences, Neurological Institute, Cleveland Clinic, Cleveland, OH, United States.
Complex Regional Pain Syndrome (CRPS) is a chronic pain disorder characterized by a diverse array of symptoms, including pain that is disproportionate to the initial triggering event, accompanied by autonomic, sensory, motor, and sudomotor disturbances. The primary pathology of both types of CRPS (Type I, also known as reflex sympathetic dystrophy, RSD; Type II, also known as causalgia) is featured by allodynia, edema, changes in skin color and temperature, and dystrophy, predominantly affecting extremities. Recent studies started to unravel the complex pathogenic mechanisms of CRPS, particularly from an autoimmune and neuroimmune interaction perspective.
View Article and Find Full Text PDFCRPS: what's in a name? Taxonomy, epidemiology, neurologic, immune and autoimmune considerations.
Reg Anesth Pain Med
March 2019
Department of Pain Management, Cleveland Clinic, Cleveland, OH 44024, USA
This account of the condition now termed complex regional pain syndrome (CRPS) spans approximately 462 years since a description embodying similar clinical features was described by Ambroise Paré in 1557. While reviewing its historical origins, the text describes why it became necessary to change the taxonomies of two clinical syndromes with similar pathophysiologies to one which acknowledges this aspect but does not introduce any mechanistic overtones. Discussed at length is the role of the sympathetic component of the autonomic nervous system (ANS) and why its dysfunction has both directly and indirectly influenced our understanding of the inflammatory aspects of CRPS.
View Article and Find Full Text PDFNeural mechanisms underlying deafferentation pain: a hypothesis from a neuroimaging perspective.
J Orthop Sci
May 2012
Department of Molecular Imaging, Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo, 187-8551, Japan.
Deafferentation pain following nerve injury annoys patients, and its management is a challenge in clinical practice. Although the mechanisms underlying deafferentation pain remain poorly understood, progress in the development of multidimensional neuroimaging techniques is casting some light on these issues. Deafferentation pain likely results from reorganization of the nervous system after nerve injury via processes that interact with the substrates for pain perception (the pain matrix).
View Article and Find Full Text PDFOrofacial pain mechanisms and their clinical application.
Dent Clin North Am
April 1997
Department of Orofacial Pain, University of California, Los Angeles Dental School, USA.
This article has discussed the peripheral and central mechanisms of the various orofacial pain conditions, including musculoskeletal disorders, neurogenic inflammation, and neuropathic pain. To make an accurate diagnosis of orofacial pain and render treatment, all organ systems need to be considered and evaluated. Central sensitization was discussed as it relates to musculoskeletal disorders and neuropathic pain.
View Article and Find Full Text PDF[Causalgia in the light of new findings].
Vojnosanit Pregl
February 1996
Vojnomedicinska akademija, Klinika za neurologiju, Beograd.
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