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A Complicated Triad of Diabetic Ketoacidosis, Hypertriglyceridemia, and Acute Pancreatitis in a Patient With Alcohol Abuse and Undiagnosed Diabetes Mellitus.
Cureus
December 2024
Medical School, Edward Via College of Osteopathic Medicine, Auburn, USA.
Diabetic ketoacidosis (DKA), hypertriglyceridemia, and acute pancreatitis are a rare and potentially fatal triad. This article presents a fatal case of acute pancreatitis, DKA, and hypertriglyceridemia in a patient with undiagnosed diabetes mellitus struggling with alcoholism. The patient was unresponsive to standard pancreatitis and DKA treatment protocol and progressed to develop multi-organ failure.
View Article and Find Full Text PDFEffect of Dietary Ketosis and Nicotinamide Riboside on Hippocampal Krebs Cycle Intermediates and Mitochondrial Energetics in a DNA Repair-Deficient 3xTg/POLβ Alzheimer Disease Mouse Model.
J Neurochem
January 2025
The Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Alzheimer disease is a neurodegenerative pathology-modifying mitochondrial metabolism with energy impairments where the effects of biological sex and DNA repair deficiencies are unclear. We investigated the therapeutic potential of dietary ketosis alone or with supplemental nicotinamide riboside (NR) on hippocampal intermediary metabolism and mitochondrial bioenergetics in older male and female wild-type (Wt) and 3xTgAD-DNA polymerase-β-deficient (3xTg/POLβ) (AD) mice. DNA polymerase-β is a key enzyme in DNA base excision repair (BER) of oxidative damage that may also contribute to mitochondrial DNA repair.
View Article and Find Full Text PDFAuthors reply to comment on Hayman et al. "elevated osmol gaps in patients with alcoholic ketoacidosis".
Clin Toxicol (Phila)
January 2025
Division of Medical Toxicology, Ronald O. Perelman Department of Emergency Medicine, NYU Grossman School of Medicine, New York, NY, USA.
[Chapters from alcohology].
Orv Hetil
December 2024
1 Elméleti Biológiai Kutatócsoport Budapest Magyarország.
Comment on "Elevated osmol gaps in patients with alcoholic ketoacidosis".
Clin Toxicol (Phila)
January 2025
Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
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