The effects of atrial natriuretic factor (ANF) on norepinephrine (NE) uptake in circumventricular organs (organum vasculosum lamina terminalis, organum subfornicale and area postrema), locus coeruleus and nucleus tractus solitarii were studied in the rat. Experiments were carried out in vitro using nuclei obtained according to the punch-out technique. Results showed that 100 nM ANF enhanced NE uptake in all nuclei studied. These results suggest that ANF may be indirectly related to the control of cardiocirculatory functions, hydroelectrolyte balance, neuroendocrine secretions, nutrient and metabolic homeostasis, through the modulation of noradrenergic neurotransmission at the neuronal presynaptic level.
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