AI Article Synopsis
- The study examines interleukin-1 beta (Il-1 beta) levels in the extracellular fluid of male rats over various time intervals after inserting a push-pull cannula in the hypothalamus.
- Results show that Il-1 beta levels were consistent at 24 and 72 hours post-implantation, but significantly increased at the 7-day mark when compared to earlier measurements.
- The findings suggest that Il-1 beta concentrations in the brain are influenced by both the sampling method and the duration since the cannula was implanted, indicating a complex relationship within the intracerebral environment.
Article Abstract
Interleukin-1 beta (Il-1 beta) concentrations in extracellular fluid (ECF) withdrawn at 10-min intervals through a push-pull cannula (PPC) located in the hypothalamus were studied in freely behaving male rats for 1 h at 24 and 72 h and again at 7 days after PPC implantation. Il-1 beta concentrations in ECF were similar in the latter. However, when ECF was sampled at 3 h and again 7 days after PPC implantation, Il-1 beta concentrations were greatly elevated at 7 days when compared to all other intervals. These results demonstrate how the relationships between Il-1 beta measured in ECF and the conditions of measurement appear to be integral parts of a whole intracerebral system: cytokine concentrations appear to be inextricably bound to intrahypothalamic conditions created by the sampling device presence and frequency of use.
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| http://dx.doi.org/10.1016/0006-8993(95)00491-8 | DOI Listing |
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