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Remote ischemic preconditioning on perioperative autonomic nervous system function and postoperative recovery in patients undergoing cholecystectomy.
Scand J Gastroenterol
January 2025
Department of Anesthesiology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Background: Cholecystectomy often disrupts autonomic balance, impacting recovery. Remote ischemic preconditioning (RIPC) may enhance ANS function and protect organs, but its role in cholecystectomy is unclear.
Methods: In this randomized controlled trial, 80 patients aged 45 to 65 years, scheduled for elective laparoscopic cholecystectomy, were randomly assigned to either the RIPC group or the control group.
Preconditioning of Mesenchymal Stem Cells Enhances the Neuroprotective Effects of Their Conditioned Medium in an Alzheimer's Disease In Vitro Model.
Biomedicines
October 2024
Institute of Biomedical Chemistry, Pogodinskaya 10, 119121 Moscow, Russia.
Article Synopsis
- The study investigates the neuroprotective effects of conditioned medium (CM) from mesenchymal stem cells (MSCs) that have been activated or pretreated to enhance their therapeutic properties in the context of Alzheimer's disease (AD).
- Results show that CM from activated MSCs has stronger anti-inflammatory effects and improves neuron cell viability under oxidative stress, potentially by increasing the production of growth factors.
- The research highlights the mechanism behind these effects, including the modulation of microglial activity and the activation of the Nrf2/ARE pathway in neuron-like cells.
High-intensity interval training alleviates liver inflammation by regulating the TLR4/NF-κB signaling pathway and M1/M2 macrophage balance in female rats with cisplatin hepatotoxicity.
Biochem Biophys Res Commun
November 2024
Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista, Bahia, 45029-094, Brazil. Electronic address:
Cisplatin (CDDP) is an antineoplastic drug whose adverse effects include hepatotoxicity. The inflammatory process is crucial in the progression of liver injuries. Exercise is known for its anti-inflammatory effects, but the influence of different training modalities on hepatoprotection is still unclear.
View Article and Find Full Text PDFAerobic interval training preconditioning protocols inhibit isoproterenol-induced pathological cardiac remodeling in rats: Implications on oxidative balance, autophagy, and apoptosis.
Sports Med Health Sci
December 2024
Department of Exercise Physiology and Corrective Exercises, Faculty of Sport Sciences, Urmia University, Urmia, Iran.
This study aimed to investigate the potential cardioprotective effects of moderate and high-intensity aerobic interval training (MIIT and HIIT) preconditioning. The focus was on histological changes, pro-oxidant-antioxidant balance, autophagy initiation, and apoptosis in myocardial tissue incited by isoproterenol-induced pathological cardiac remodeling (ISO-induced PCR). Male Wistar rats were randomly divided into control ( = 6), ISO ( = 8), MIIT ( = 4), HIIT ( = 4), MIIT + ISO ( = 8), and HIIT + ISO ( = 8) groups.
View Article and Find Full Text PDFRemote ischemic preconditioning prevents high-altitude cerebral edema by enhancing glucose metabolic reprogramming.
CNS Neurosci Ther
September 2024
Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University, Beijing, China.
Aims: Incidence of acute mountain sickness (AMS) ranges from 40%-90%, with high-altitude cerebral edema (HACE) representing a life-threatening end stage of severe AMS. However, practical and convenient preventive strategies for HACE are lacking. Remote ischemic preconditioning (RIPC) has demonstrated preventive effects on ischemia- or hypoxia-induced cardiovascular and cerebrovascular diseases.
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