AI Article Synopsis
- SB 205952 is a nitrofuryl oxazole derivative with better antimicrobial potency than mupirocin, especially against mupirocin-resistant staphylococci.
- It effectively inhibits bacterial isoleucyl-tRNA synthetase in susceptible bacteria but not in resistant strains, suggesting multiple action mechanisms.
- SB 205952 disrupts protein, RNA, and DNA synthesis in both susceptible and resistant staphylococci, with RNA synthesis inhibition likely being a secondary effect influenced by stringent control.
Article Abstract
The biological properties of SB 205952, a nitrofuryl oxazole derivative of monic acid, differ from those of the closely related antibacterial agent mupirocin. Compared with mupirocin, SB 205952 has increased antimicrobial potency, an extended spectrum including mupirocin-resistant staphylococci, and rapid bactericidal activity. SB 205952, like mupirocin, is a potent inhibitor of bacterial isoleucyl-tRNA synthetase (IRS) in mupirocin-susceptible organisms but does not inhibit IRS from mupirocin-resistant staphylococci, indicating that SB 205952 has more than one mechanism of action. SB 205952 rapidly inhibits protein, RNA, and DNA syntheses in mupirocin-susceptible and mupirocin-resistant staphylococci. In each case, the effect on RNA synthesis is relaxed by treatment with chloramphenicol, indicating that inhibition of RNA synthesis is probably a secondary consequence of stringent control. It is proposed that SB 205952 possesses one or more mechanisms of action in addition to IRS inhibition, probably mediated by its nitrofuryl component.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC162858 | PMC |
| http://dx.doi.org/10.1128/AAC.39.9.1925 | DOI Listing |
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